Protein detail

S22AG

Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)

Entry name S22AG	UniProt ID Q86VW1	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 12	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)

Protein Class (3)

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

23..43; Helical; 152..172; Helical; 183..203; Helical; 214..234; Helical; 244..264; Helical; 268..288; Helical; 359..379; Helical; 389..409; Helical; 416..436; Helical; 441..461; Helical; 476..496; Helical; 501..521; Helical

Transmembrane Count

Ensembl

ENSG00000004809

Entrez Gene Symbol

SLC22A16

Gene Synonym (4)

CT2FLIPT2OAT6OKB1

Gene Description

Solute carrier family 22 member 16

Chromosome

Position

110424687-110476641

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificB-cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (3)

Molecular Function (4)

Reactome (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence28

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ACSM1 APBA3 NFX1 PDHA2 SLC22A16	O96018 P29803 Q08AH1 Q12986 Q86VW1	0:0:0:0:0	hu.MAP2
ACSM1 GBP5 SLC22A16	Q08AH1 Q86VW1 Q96PP8	0:0:0	hu.MAP2
ACSM1 CPEB1 GBP5 SLC22A16	Q08AH1 Q86VW1 Q96PP8 Q9BZB8	0:0:0:0	hu.MAP2
GBP5 SLC22A16	Q86VW1 Q96PP8	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [MALDI TOF]\|Mass spectrometry [QTOF]Mass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]R Sequencing	4	33184263 33184263 36532861 36532861

Sequence, Structure & Domains9

Sequences

Length

577

Mass

64,614

Sequence

MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86VW1-1; Sequence=Displayed; Name=2; IsoId=Q86VW1-2; Sequence=VSP_031336, VSP_031337; Name=3; IsoId=Q86VW1-3; Sequence=VSP_031338

Alternative Sequence

1..17; MGSRHFEGIYDHVGHFG -> MRTLHAVSHPYSNSM (in isoform 2); 58..89; Missing (in isoform 2); 509..577; FVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE -> LGQHLQE (in isoform 3)

Domain & Motif Annotations

Compositional Bias

551..560; Low complexity

Region

543..577; Disordered

Protein Families (2)

Major facilitator (TC 2.A.1) superfamily
Organic cation transporter (TC 2.A.1.19) family

Sequence Similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Clinical Relevance2

Drugs (2)

FLUOROURACIL NULL

Antibody

HPA036902

Supporting Publications3

PMID	Title	Abstract
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available