Protein detail
AMGO1
Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2)
Protein symbol AMGO1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
373..393; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
AMIGOKIAA1163
Gene Description
Adhesion molecule with Ig like domain 1
Chromosome
1
Position
109504178-109509738
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificBreast lactating cellsSecretome LocationSecreted in other tissuesSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component
Biological Process
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster70 | AMIGO1BDH1CASP3CASP6CASP7COQ6DHRS9FBXL12LCMT1LCMT2RDH16SDR9C7 | O60294O75452P42574P55210P55212Q02338Q86WK6Q8NEX9Q9BPW9Q9NXK8Q9UIC8Q9Y2Z9 | 1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC1738 | 22036573 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 39408670 |
Sequence, Structure & Domains
Sequences
Length
493
Mass
55,239
Sequence
MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHLGDTLIIKCDTKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV
3D Structural Models
Domain & Motif Annotations
Compositional Bias
408..424; Polar residues; 431..442; Basic and acidic residues
Repeat
62..83; LRR 1; 87..108; LRR 2; 111..132; LRR 3; 135..156; LRR 4; 159..179; LRR 5; 186..206; LRR 6
Domain (CC)
The LRR repeat region mediates homodimerization.
Domain (FT)
28..61; LRRNT; 221..272; LRRCT; 269..353; Ig-like C2-type
Region
405..493; Disordered
Protein Families
- Immunoglobulin superfamily
- AMIGO family
Sequence Similarities
Belongs to the immunoglobulin superfamily. AMIGO family.