Protein detail
AMGO1
Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2)
Entry name AMGO1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
373..393; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
AMIGOKIAA1163
Gene Description
Adhesion molecule with Ig like domain 1
Chromosome
1
Position
109504178-109509738
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization4
Tissue SpecificesophagusCell SpecificBreast lactating cellsSecretome LocationSecreted in other tissuesSecretome FunctionCell adhesion
Function & Pathway5
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence33
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
Protein Complex Composition (1)
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster70 | AMIGO1BDH1CASP3CASP6CASP7COQ6DHRS9FBXL12LCMT1LCMT2RDH16SDR9C7 | O60294O75452P42574P55210P55212Q02338Q86WK6Q8NEX9Q9BPW9Q9NXK8Q9UIC8Q9Y2Z9 | 1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC1738 | 22036573 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 39408670 |
Sequence, Structure & Domains10
Sequences
Length
493
Mass
55,239
Sequence
MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHLGDTLIIKCDTKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV
Domain & Motif Annotations
Compositional Bias
408..424; Polar residues; 431..442; Basic and acidic residues
Repeat
62..83; LRR 1; 87..108; LRR 2; 111..132; LRR 3; 135..156; LRR 4; 159..179; LRR 5; 186..206; LRR 6
Domain (CC)
The LRR repeat region mediates homodimerization.
Domain (FT)
28..61; LRRNT; 221..272; LRRCT; 269..353; Ig-like C2-type
Region
405..493; Disordered
Protein Families (2)
- Immunoglobulin superfamily
- AMIGO family
Sequence Similarities
Belongs to the immunoglobulin superfamily. AMIGO family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |