Protein detail
ANKL2
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
Entry name ANKL2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
Protein Class (5)
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Transmembrane
13..32; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
KIAA0692Lem4LEMD7
Gene Description
Ankyrin repeat and LEM domain containing 2
Chromosome
12
Position
132725503-132761832
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificmammillary bodyBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (10)
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-2995383 initiation of nuclear envelope ne reformation
- R-hsa-2555396 mitotic metaphase and anaphase
- R-hsa-68886 m phase
- R-hsa-2995410 nuclear envelope ne reassembly
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Receptor-signaling mediation
Relations & Evidence19
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ANKLE2 | CDK2 | P24941 | S | 528 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane_predicted | transmembrane | OmniPath | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANKLE2PPP2CBPPP2R3BTBCCD1 | P62714Q86XL3Q9NVR7Q9Y5P8 | 0:0:0:0 | hu.MAP | |||
| ANKLE2CUL7FEM1CGLMNZSWIM6 | Q14999Q86XL3Q92990Q96JP0Q9HCJ5 | 0:0:0:0:0 | hu.MAP2 | |||
| ANKLE2GHITMMTFR1LSARM1UQCC6 | Q69YU5Q6SZW1Q86XL3Q9H019Q9H3K2 | 0:0:0:0:0 | hu.MAP2 | |||
| ANKLE2ARRDC1FEM1CGLMNZSWIM6 | Q86XL3Q8N5I2Q92990Q96JP0Q9HCJ5 | 0:0:0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
938
Mass
104,114
Sequence
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEETSSPVIGELWSPDQTAEASHVSRYGGSPRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSGSNSISVRAFLDEDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPRGEEAHLPPVSDLTVEFDKLNLQNIGRSVSKTPDESTKTKDQILTSRINAVERDLLEPSPADQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPDLSGPHSYSPGRNSVAGSNPAKPGLGSPGRYSPVHGSQLRRMARLAELAAL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86XL3-1; Sequence=Displayed; Name=2; IsoId=Q86XL3-2; Sequence=VSP_023574, VSP_023575; Name=3; IsoId=Q86XL3-3; Sequence=VSP_044173
Alternative Sequence
1..645; Missing (in isoform 3); 631..648; GSNSISVRAFLDEDDMSL -> VEMRFHRIDQAGLELLTS (in isoform 2); 649..938; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
609..627; Basic and acidic residues
Repeat
411..440; ANK
Domain (FT)
69..113; LEM
Region
609..636; Disordered; 870..924; Disordered
Protein Families
ANKLE2 family
Sequence Similarities
Belongs to the ANKLE2 family.
Clinical Relevance
Disease Involvement (2)
Disease variantPrimary microcephaly
Related Diseases
Interaction Protein (3)
ENSG00000104695ENSG00000105568ENSG00000113575
Interaction Count
3
Interaction Dataset (3)
biogrid_bioplexintact_biogrid_bioplexbiogrid_opencell
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |