Protein detail
ANKL2
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
Protein symbol ANKL2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Transmembrane
13..32; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0692Lem4LEMD7
Gene Description
Ankyrin repeat and LEM domain containing 2
Chromosome
12
Position
132725503-132761832
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificmammillary bodyBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-2995383 initiation of nuclear envelope ne reformation
- R-hsa-2555396 mitotic metaphase and anaphase
- R-hsa-68886 m phase
- R-hsa-2995410 nuclear envelope ne reassembly
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ANKLE2 | CDK2 | P24941 | S | 528 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANKLE2PPP2CBPPP2R3BTBCCD1 | P62714Q86XL3Q9NVR7Q9Y5P8 | 0:0:0:0 | hu.MAP | |||
| ANKLE2CUL7FEM1CGLMNZSWIM6 | Q14999Q86XL3Q92990Q96JP0Q9HCJ5 | 0:0:0:0:0 | hu.MAP2 | |||
| ANKLE2GHITMMTFR1LSARM1UQCC6 | Q69YU5Q6SZW1Q86XL3Q9H019Q9H3K2 | 0:0:0:0:0 | hu.MAP2 | |||
| ANKLE2ARRDC1FEM1CGLMNZSWIM6 | Q86XL3Q8N5I2Q92990Q96JP0Q9HCJ5 | 0:0:0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
938
Mass
104,114
Sequence
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEETSSPVIGELWSPDQTAEASHVSRYGGSPRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSGSNSISVRAFLDEDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPRGEEAHLPPVSDLTVEFDKLNLQNIGRSVSKTPDESTKTKDQILTSRINAVERDLLEPSPADQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPDLSGPHSYSPGRNSVAGSNPAKPGLGSPGRYSPVHGSQLRRMARLAELAAL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86XL3-1; Sequence=Displayed; Name=2; IsoId=Q86XL3-2; Sequence=VSP_023574, VSP_023575; Name=3; IsoId=Q86XL3-3; Sequence=VSP_044173
Alternative Sequence
1..645; Missing (in isoform 3); 631..648; GSNSISVRAFLDEDDMSL -> VEMRFHRIDQAGLELLTS (in isoform 2); 649..938; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
609..627; Basic and acidic residues
Repeat
411..440; ANK
Domain (FT)
69..113; LEM
Region
609..636; Disordered; 870..924; Disordered
Protein Families
ANKLE2 family
Sequence Similarities
Belongs to the ANKLE2 family.