Protein detail
XYLT1
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
Protein symbol XYLT1 | UniProt ID | EVMP score 0.72 |
Frequency 16 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins |
Basic Information
Protein Names
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Transmembrane
18..38; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PXYLT1XT-I
Gene Description
Xylosyltransferase 1
Chromosome
16
Position
17101769-17470960
Frequency
16
EVMP Score
0.72
Fluorescence & Localization
Cell SpecificPlatelets
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Cellular Component
Biological Process
KEGG
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Fukutin-FKRP-TMEM5 multienzyme complex | FKRPFKTNRXYLT1 | O75072Q9H9S5Q9Y2B1 | 1:1:1 | ComplexPortal | intact:EBI-40265839 | 2947784214755292 |
| FKTNRXYLT1 | O75072Q9Y2B1 | 0:0 | hu.MAP2 | |||
| SDC1XYLT1 | P18827Q86Y38 | 1:1 | PDB | PDB:6eje | ||
| GALNT18GXYLT1 | Q4G148Q6P9A2 | 0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
959
Mass
107,569
Sequence
MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR
3D Structural Models
Turn
442..444; 463..465; 564..568; 602..604; 625..628; 707..710; 748..751; 876..880
Helix
262..270; 274..288; 315..318; 339..349; 365..377; 396..410; 432..441; 455..462; 500..508; 512..520; 521..523; 527..529; 531..538; 542..544; 557..560; 581..588; 607..617; 637..639; 641..643; 646..665; 852..859; 873..875; 885..895; 899..913; 933..935; 945..947
Beta Strand
303..305; 328..334; 354..360; 381..383; 417..422; 426..430; 446..448; 466..471; 474..480; 497..499; 545..547; 550..553; 569..571; 596..598; 629..636; 677..691; 694..706; 711..721; 737..747; 752..755; 767..772; 774..776; 778..785; 791..799; 805..808; 818..827; 830..839; 843..845; 865..870; 914..923; 936..939
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Compositional Bias
78..104; Gly residues; 145..161; Basic and acidic residues; 163..172; Polar residues; 177..204; Basic and acidic residues; 249..259; Basic and acidic residues
Region
42..259; Disordered; 940..959; Disordered
Protein Families
- Glycosyltransferase 14 family
- XylT subfamily
Sequence Similarities
Belongs to the glycosyltransferase 14 family. XylT subfamily.