Protein detail

XYLT1

Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)

Entry name XYLT1	UniProt ID Q86Y38	EVMP confidence score 0.72
Supporting publications (n) 16	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins

Protein Function (8)

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Congenital malformations of skin
Disease related genes

Transmembrane

18..38; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000103489

Entrez Gene Symbol

XYLT1

Gene Synonym (2)

PXYLT1XT-I

Gene Description

Xylosyltransferase 1

Chromosome

Position

17101769-17470960

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization2

Cell SpecificPlatelets

Function & Pathway7

Protein Function (8)

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Congenital malformations of skin
Disease related genes

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

KEGG (3)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence21

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	TopDB	No	No	Yes	No	No
transmembrane	transmembrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Fukutin-FKRP-TMEM5 multienzyme complex	FKRP FKTN RXYLT1	O75072 Q9H9S5 Q9Y2B1	1:1:1	ComplexPortal	intact:EBI-40265839	29477842 14755292
	FKTN RXYLT1	O75072 Q9Y2B1	0:0	hu.MAP2
	SDC1 XYLT1	P18827 Q86Y38	1:1	PDB	PDB:6eje
	GALNT18 GXYLT1	Q4G148 Q6P9A2	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	4	33204424 37786918 34817906 28986585

Sequence, Structure & Domains11

Sequences

Length

959

Mass

107,569

Sequence

MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR

3D Structural Models

Turn

442..444; 463..465; 564..568; 602..604; 625..628; 707..710; 748..751; 876..880

Helix

262..270; 274..288; 315..318; 339..349; 365..377; 396..410; 432..441; 455..462; 500..508; 512..520; 521..523; 527..529; 531..538; 542..544; 557..560; 581..588; 607..617; 637..639; 641..643; 646..665; 852..859; 873..875; 885..895; 899..913; 933..935; 945..947

Beta Strand

303..305; 328..334; 354..360; 381..383; 417..422; 426..430; 446..448; 466..471; 474..480; 497..499; 545..547; 550..553; 569..571; 596..598; 629..636; 677..691; 694..706; 711..721; 737..747; 752..755; 767..772; 774..776; 778..785; 791..799; 805..808; 818..827; 830..839; 843..845; 865..870; 914..923; 936..939

3D Structure

X-ray crystallography (9)

Domain & Motif Annotations

Compositional Bias

78..104; Gly residues; 145..161; Basic and acidic residues; 163..172; Polar residues; 177..204; Basic and acidic residues; 249..259; Basic and acidic residues

Region

42..259; Disordered; 940..959; Disordered

Protein Families (2)

Glycosyltransferase 14 family
XylT subfamily

Sequence Similarities

Belongs to the glycosyltransferase 14 family. XylT subfamily.

Clinical Relevance2

Disease Involvement (2)

Disease variantDwarfism

Antibody (2)

HPA007478 HPA007966

Supporting Publications16

PMID	Title	Abstract
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	No abstract available
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
33035814	Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
35194965	Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles.	No abstract available

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