Protein detail
XYLT1
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
Entry name XYLT1 | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 16 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins
Protein Function (8)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Transmembrane
18..38; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
PXYLT1XT-I
Gene Description
Xylosyltransferase 1
Chromosome
16
Position
17101769-17470960
Supporting publications (n)
16
EVMP confidence score
0.47
Fluorescence & Localization
Cell SpecificPlatelets
Function & Pathway
Protein Function (8)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
KEGG (3)
Reactome (3)
Mediation Categories
Metabolism mediation
Relations & Evidence21
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| secreted | secreted | UniProt_keyword | Yes | ||||
| secreted | secreted | UniProt_location | Yes | ||||
| secreted | secreted | HPA_secretome | Yes | ||||
| secreted | secreted | OmniPath | Yes |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Fukutin-FKRP-TMEM5 multienzyme complex | FKRPFKTNRXYLT1 | O75072Q9H9S5Q9Y2B1 | 1:1:1 | ComplexPortal | intact:EBI-40265839 | 2947784214755292 |
| FKTNRXYLT1 | O75072Q9Y2B1 | 0:0 | hu.MAP2 | |||
| SDC1XYLT1 | P18827Q86Y38 | 1:1 | PDB | PDB:6eje | ||
| GALNT18GXYLT1 | Q4G148Q6P9A2 | 0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
959
Mass
107,569
Sequence
MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR
3D Structural Models
Turn
442..444; 463..465; 564..568; 602..604; 625..628; 707..710; 748..751; 876..880
Helix
262..270; 274..288; 315..318; 339..349; 365..377; 396..410; 432..441; 455..462; 500..508; 512..520; 521..523; 527..529; 531..538; 542..544; 557..560; 581..588; 607..617; 637..639; 641..643; 646..665; 852..859; 873..875; 885..895; 899..913; 933..935; 945..947
Beta Strand
303..305; 328..334; 354..360; 381..383; 417..422; 426..430; 446..448; 466..471; 474..480; 497..499; 545..547; 550..553; 569..571; 596..598; 629..636; 677..691; 694..706; 711..721; 737..747; 752..755; 767..772; 774..776; 778..785; 791..799; 805..808; 818..827; 830..839; 843..845; 865..870; 914..923; 936..939
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Compositional Bias
78..104; Gly residues; 145..161; Basic and acidic residues; 163..172; Polar residues; 177..204; Basic and acidic residues; 249..259; Basic and acidic residues
Region
42..259; Disordered; 940..959; Disordered
Protein Families (2)
- Glycosyltransferase 14 family
- XylT subfamily
Sequence Similarities
Belongs to the glycosyltransferase 14 family. XylT subfamily.
Clinical Relevance
Supporting Publications16
| PMID | Title | Related sentences |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No related sentences available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No related sentences available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 35194965 | Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles. | No related sentences available |
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