Protein detail
TRML1
Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)
Protein symbol TRML1 | UniProt ID | EVMP score 0.50 |
Frequency 7 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)
Protein Class
Plasma proteinsPredicted membrane proteins
Transmembrane
163..183; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
dJ238O23.3TLT1
Gene Description
Triggering receptor expressed on myeloid cells like 1
Chromosome
6
Position
41149337-41154347
Frequency
7
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificEpicardial cellsSingle-Nuclei Brain Specifichippocampal CA1-3Blood Cell SpecificgdT-cellBlood Lineage SpecificNK-cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Cellular Component
Biological Process
Reactome
Mediation Categories
Immune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| ig_like | receptor | Almen2009 | No | Yes | No | Yes | No |
| triggering | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 17 | 3320442439766158363985643778691839940923394090153720509834817906289865852789410430950185383215353955813439569406304085913208974329148239 |
Sequence, Structure & Domains
Sequences
Length
311
Mass
32,679
Sequence
MGLTLLLLLLLGLEGQGIVGSLPEVLQAPVGSSILVQCHYRLQDVKAQKVWCRFLPEGCQPLVSSAVDRRAPAGRRTFLTDLGGGLLQVEMVTLQEEDAGEYGCMVDGARGPQILHRVSLNILPPEEEEETHKIGSLAENAFSDPAGSANPLEPSQDEKSIPLIWGAVLLVGLLVAAVVLFAVMAKRKQGNRLGVCGRFLSSRVSGMNPSSVVHHVSDSGPAAELPLDVPHIRLDSPPSFDNTTYTSLPLDSPSGKPSLPAPSSLPPLPPKVLVCSKPVTYATVIFPGGNKGGGTSCGPAQNPPNNQTPSS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86YW5-1; Sequence=Displayed; Name=2; Synonyms=TLT1sv; IsoId=Q86YW5-2; Sequence=VSP_021125, VSP_021126; Name=3; IsoId=Q86YW5-3; Sequence=VSP_021124
Alternative Sequence
15..125; Missing (in isoform 3); 190..199; GNRLGVCGRF -> ESLLSGPPRQ (in isoform 2); 200..311; Missing (in isoform 2)
3D Structural Models
Turn
74..76; 139..142
Helix
42..44; 96..98; 135..137
Beta Strand
24..28; 34..39; 47..55; 58..64; 70..73; 77..83; 86..91; 100..108; 111..122
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
239..249; Polar residues
Motif
279..284; ITIM
Domain (FT)
16..121; Ig-like V-type
Region
229..263; Disordered; 287..311; Disordered