Protein detail

RB6I2

ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)

Entry name
RB6I2
UniProt ID
Q8IUD2
EVMP confidence score
0.72
Supporting publications (n)
20
Transmembrane count
Protein classification
Cancer-related genesDisease related genesPredicted intracellular proteins
Basic Information
Protein Names
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)
Protein Class (3)
Cancer-related genesDisease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Cancer-related genes
Ensembl
ENSG00000082805
Entrez Gene Symbol
ERC1
Gene Synonym (5)
CAST2ELKSKIAA1081MGC12974RAB6IP2
Gene Description
ELKS/RAB6-interacting/CAST family member 1
Chromosome
12
Position
990509-1495933
Supporting publications (n)
20
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecificovaryCell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Cancer-related genes
Cellular Component (10)
Molecular Function (5)
Biological Process (3)
KEGG (2)
Canonical Pathways (3)
  • M237 Pid vegfr1 2 pathway
  • M48 Pid met pathway
  • M186 Pid pdgfrb pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence25

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularOmniPath
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location

Regulatory Interaction Network (2)

2 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
RB6I2Q8IUD2IKKAO15111YesYesWangMacrophageSIGNORMacrophage:17072322SIGNOR:15218148Macrophage:16970925Macrophage:15218526Macrophage:16497931Macrophage:15371334
RB6I2Q8IUD2COMPLEX:O14920_O15111_Q9Y6K9YesYesSIGNORSIGNOR:15218148

Protein Complex Composition (17)

17 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ERC1TSHBP01222Q8IUD20:0hu.MAP2
HERC1TENT4ATENT4BUBCUHMK1ZCCHC7P0CG48Q15751Q5XG87Q8N3Z6Q8NDF8Q8TAS11:1:1:1:1:1NetworkBlastCompleatCompleat:HC4196
HERC1MTREXTENT4ATENT4BUHMK1ZCCHC7P42285Q15751Q5XG87Q8N3Z6Q8NDF8Q8TAS11:1:1:1:1:1NetworkBlastCompleatCompleat:HC9651
HERC1Q157514PDBPDB:4o2w
HERC1IFIT1BQ15751Q5T7640:0hu.MAP2
CCDC65HERC1IFIT1BQ15751Q5T764Q8IXS20:0:0hu.MAP2
HERC1MORC1MORC2Q15751Q86VD1Q9Y6X90:0:0hu.MAP
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry433204424397661583994092327894104
Sequence, Structure & Domains

Sequences

Length
1,116
Mass
128,086
Sequence
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=ELKS epsilon; IsoId=Q8IUD2-1; Sequence=Displayed; Name=2; Synonyms=ELKS beta; IsoId=Q8IUD2-2; Sequence=VSP_011451, VSP_011452, VSP_011454, VSP_011455; Name=3; Synonyms=ELKS delta; IsoId=Q8IUD2-3; Sequence=VSP_011451; Name=4; Synonyms=ELKS alpha; IsoId=Q8IUD2-4; Sequence=VSP_011451, VSP_011452, VSP_011453, VSP_011454, VSP_011455; Name=5; Synonyms=ELKS gamma; IsoId=Q8IUD2-5; Sequence=VSP_011450, VSP_011452, VSP_011454, VSP_011455
Alternative Sequence
224..523; Missing (in isoform 5); 440..467; Missing (in isoform 2, isoform 3 and isoform 4); 783; E -> ESLTS (in isoform 2, isoform 4 and isoform 5); 830..873; Missing (in isoform 4); 1009..1016; IIQPLLEL -> DEEEGIWA (in isoform 2, isoform 4 and isoform 5); 1017..1116; Missing (in isoform 2, isoform 4 and isoform 5)

Domain & Motif Annotations

Compositional Bias
13..28; Low complexity; 40..51; Gly residues; 590..602; Basic and acidic residues
Coiled Coil
144..988; 1060..1100
Domain (FT)
1046..1108; FIP-RBD
Region
1..54; Disordered; 590..609; Disordered; 814..836; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Antibody (3)
HPA019513HPA019523HPA024130
Interaction Protein (2)
ENSG00000046651ENSG00000170027
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications20
PMIDTitleRelated sentences
36635400Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study.No related sentences available
37686366Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.No related sentences available
37702715One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles.No related sentences available
38082559Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia.No related sentences available
38164498Enrichment of sweat-derived extracellular vesicles of human and bacterial origin for biomarker identification.No related sentences available
38612515Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature.No related sentences available
39290459Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.No related sentences available
39835386Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid.No related sentences available
40091455Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.No related sentences available
40098346Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.No related sentences available
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