Protein detail

OSCAR

Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)

Protein symbol OSCAR	UniProt ID Q8IYS5	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000170909

Entrez Gene Symbol

OSCAR

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificCardiomyocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0038064 collagen receptor activity

Biological Process

KEGG

hsa04380 Osteoclast differentiation

Reactome

Mediation Categories

Immune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	No	No
transmembrane	transmembrane	GO_Intercell	No	No	Yes	No	No
transmembrane	transmembrane	LOCATE	No	No	Yes	No	No
transmembrane	transmembrane	OmniPath	No	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	OSCAR	Q8IYS5	2	PDB	PDB:5eiv

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	R Sequencing	5	38225453 33709510 40098346 37922300 40091455

Sequence, Structure & Domains

Sequences

Length

282

Mass

30,481

Sequence

MALVLILQLLTLWPLCHTDITPSVPPASYHPKPWLGAQPATVVTPGVNVTLRCRAPQPAWRFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGIYRCCYRRPDWGPGVWSQPSDVLELLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFVLYREGVAAPLQYRHSAQPWADFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWEGEGPEARPASSAPGMQAPGPPPSDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGV

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=OSCAR-S1; IsoId=Q8IYS5-1; Sequence=Displayed; Name=2; Synonyms=OSCAR-M1; IsoId=Q8IYS5-2; Sequence=VSP_029355; Name=3; Synonyms=OSCAR-M2; IsoId=Q8IYS5-3; Sequence=VSP_029353, VSP_029355; Name=4; Synonyms=OSCAR-S2; IsoId=Q8IYS5-4; Sequence=VSP_029352; Name=5; IsoId=Q8IYS5-5; Sequence=VSP_029354; Name=7; IsoId=Q8IYS5-7; Sequence=VSP_029353; Name=6; Synonyms=OSCAR-M3; IsoId=Q8IYS5-6; Sequence=VSP_029352, VSP_029355

Alternative Sequence

13..25; WPLCHTDITPSVP -> FP (in isoform 4 and isoform 6); 24; V -> VAIIV (in isoform 3 and isoform 7); 129..134; Missing (in isoform 5); 219..282; GEGPEARPASSAPGMQAPGPPPSDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGV -> DSGSSDYTRGNLVRLGLAGLVLISLGALVTFDWRSQNRAPAGIRP (in isoform 2, isoform 3 and isoform 6)

3D Structural Models

Turn

186..188

Helix

92..94

Beta Strand

34..39; 41..43; 49..65; 73..87; 96..103; 119..123; 125..127; 131..134; 146..151; 158..163; 166..174; 176..184; 191..198; 200..203; 213..215

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

273..282; Pro residues

Domain (FT)

22..116; Ig-like 1; 126..219; Ig-like 2

Region

221..282; Disordered

Protein Families

Leukocyte receptor complex/polymeric immunoglobulin receptor (PIR/LRC) family

Sequence Similarities

Belongs to the leukocyte receptor complex/polymeric immunoglobulin receptor (PIR/LRC) family.

Clinical Relevance