Protein detail

XRN1

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein symbol XRN1	UniProt ID Q8IZH2	EVMP score 0.63
Frequency 7	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

Basic Information

Protein Names

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein Class

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000114127

Entrez Gene Symbol

XRN1

Gene Synonym

SEP1

Gene Description

5'-3' exoribonuclease 1

Chromosome

Position

142306607-142448062

Frequency

EVMP Score

0.63

Fluorescence & Localization

Cell SpecificCardiomyocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M76 Pid p38 alpha beta pathway
M67 Pid arf6 trafficking pathway
M136 Pid foxo pathway

Mediation Categories

Clinical-translation mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

31 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_SC_Cluster388	TAFAZZIN XRN1 XRN2	Q16635 Q8IZH2 Q9H0D6	1:1:1	Compleat	Compleat:HC2919
RNA Degradation Complex	DXO RPRD1A RPRD1B RPRD2 XRN1 XRN2	O77932 Q5VT52 Q8IZH2 Q96P16 Q9H0D6 Q9NQG5	1:1:1:1:1:1	Compleat	Compleat:HC2379	15565157
RNA decapping and exonuclease complexDCP1A variant	DCP1A DCP2 DDX6 EDC3 EDC4 XRN1	P26196 Q6P2E9 Q8IU60 Q8IZH2 Q96F86 Q9NPI6	1:1:1:1:1:3	ComplexPortal	intact:EBI-9027227	34827671 14755292 24510189
RNA decapping and exonuclease complexDCP1B variant	DCP1B DCP2 DDX6 EDC3 EDC4 XRN1	P26196 Q6P2E9 Q8IU60 Q8IZD4 Q8IZH2 Q96F86	1:1:1:3:1:1	ComplexPortal	intact:EBI-30812021	34827671 14755292 24510189
mRNA decay complex (UPF1UPF2UPF3BDCP2XRN1XRN2EXOSC2EXOSC4EXOSC10PARN)	DCP2 EXOSC10 EXOSC2 EXOSC4 PARN UPF1 UPF2 UPF3B XRN1 XRN2	O95453 Q01780 Q13868 Q8IU60 Q8IZH2 Q92900 Q9BZI7 Q9H0D6 Q9HAU5 Q9NPD3	1:1:1:1:1:1:1:1:1:1	CompleatCORUM	CORUM:822Compleat:HC806	14527413
	CELF1 DKC1 EIF4E EIF4G1 EIF4G3 FBLL1 G3BP1 GAR1 KRI1 NCBP2 NHP2 RPLP0 UBC USP10 XRN1	A6NHQ2 O43432 O60832 P05388 P06730 P0CG48 P52298 Q04637 Q13283 Q14694 Q8IZH2 Q8N9T8 Q92879 Q9NX24 Q9NY12	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8102
	DCP1A DCP1B DCP2 DDX6 EDC3 LSM1 LSM3 LSM4 LSM6 LSM8 NME4 PABPC1 UPF1 XRN1 YJU2	O00746 O15116 O95777 P11940 P26196 P62310 P62312 Q8IU60 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q9BW85 Q9NPI6 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5759
	DCP1A DCP1B DCP2 DDX6 EDC3 LSM1 LSM3 LSM4 LSM6 LSM7 LSM8 SMG6 TERT UPF1 XRN1	O14746 O15116 O95777 P26196 P62310 P62312 Q86US8 Q8IU60 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q9NPI6 Q9UK45 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7072
	DCP1A GTF2H5 LSM1 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PATL1 PRPF3 PRPF4 RPS23 SART3 XRN1	O15116 O43172 O43395 O95777 P62266 P62310 P62312 Q15020 Q6ZYL4 Q86TB9 Q8IZH2 Q9NPI6 Q9UK45 Q9Y4Y9 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5606
	LSM1 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PRPF3 PRPF4 SART3 SNRPD3 SNRPN TXNL4A WSB1 XRN1	O15116 O43172 O43395 O95777 P62310 P62312 P62318 P63162 P83876 Q15020 Q8IZH2 Q9UK45 Q9Y4Y9 Q9Y4Z0 Q9Y6I7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9049

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	40595564

Sequence, Structure & Domains

Sequences

Length

1,706

Mass

194,107

Sequence

MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZH2-1; Sequence=Displayed; Name=2; IsoId=Q8IZH2-2; Sequence=VSP_016694, VSP_016695; Name=3; IsoId=Q8IZH2-3; Sequence=VSP_016692, VSP_016693

Alternative Sequence

449..459; DDFLADQAACY -> EYVFANAFILK (in isoform 3); 460..1706; Missing (in isoform 3); 1354; M -> MK (in isoform 2); 1540..1552; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1623..1642; Polar residues; 1647..1657; Low complexity; 1658..1676; Polar residues; 1677..1694; Basic residues

Region

1619..1706; Disordered

Protein Families

5'-3' exonuclease family

Sequence Similarities

Belongs to the 5'-3' exonuclease family.

Clinical Relevance

Disease Involvement

Tumor suppressor

Antibody

HPA035005 HPA035006

Interaction Protein

ENSG00000038358ENSG00000105193

Interaction Count

Interaction Dataset

intact_biogrid_opencellbiogrid_opencell