Protein detail

XRN1

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein symbol XRN1	UniProt ID Q8IZH2	EVMP score 0.63
Frequency 7	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

Basic Information

Protein Names

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein Class

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000114127

Entrez Gene Symbol

XRN1

Gene Synonym

SEP1

Gene Description

5'-3' exoribonuclease 1

Chromosome

Position

142306607-142448062

Frequency

EVMP Score

0.63

Fluorescence & Localization

Cell SpecificCardiomyocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M76 Pid p38 alpha beta pathway
M67 Pid arf6 trafficking pathway
M136 Pid foxo pathway

Mediation Categories

Clinical-translation mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

31 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DCP1A GTF2H5 LSM1 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PRPF4 RPS23 SART3 TTLL4 XRN1	O15116 O43172 O95777 P62266 P62310 P62312 Q14679 Q15020 Q6ZYL4 Q8IZH2 Q9NPI6 Q9UK45 Q9Y4Y9 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4340
DCP1A DCP1B DCP2 DDX6 EDC3 LSM1 LSM3 LSM4 LSM6 LSM7 LSM8 UBC UPF1 USP28 XRN1	O15116 O95777 P0CG48 P26196 P62310 P62312 Q8IU60 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q96RU2 Q9NPI6 Q9UK45 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8160
DCP1A DCP1B DCP2 DDX6 EDC3 LSM1 LSM3 LSM4 LSM6 LSM7 LSM8 RPS23 TTLL4 UPF1 XRN1	O15116 O95777 P26196 P62266 P62310 P62312 Q14679 Q8IU60 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q9NPI6 Q9UK45 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4276
DCP1A DCP1B DCP2 DDX6 EDC3 LSM1 LSM3 LSM4 LSM6 LSM7 LSM8 POLA2 RBM23 UPF1 XRN1	O15116 O95777 P26196 P62310 P62312 Q14181 Q86U06 Q8IU60 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q9NPI6 Q9UK45 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9336
DCP1A DCP1B DCP2 DDX6 EDC3 LSM1 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 SART3 UPF1 XRN1	O15116 O95777 P26196 P62310 P62312 Q15020 Q8IU60 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q9NPI6 Q9UK45 Q9Y4Y9 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9543
CSNK2A1 DKC1 EIF4G1 EIF4G3 G3BP1 H2AC18 KRI1 POLDIP3 RPLP0 SRSF2 UBC USP10 XRN1	O43432 O60832 P05388 P0CG48 P68400 Q01130 Q04637 Q13283 Q14694 Q6FI13 Q8IZH2 Q8N9T8 Q9BY77	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4822
CELF1 CSNK2A1 DKC1 EIF4E EIF4G1 EIF4G3 G3BP1 KRI1 NCBP1 POLDIP3 SRSF2 UBC USP10 XRN1	O43432 O60832 P06730 P0CG48 P68400 Q01130 Q04637 Q09161 Q13283 Q14694 Q8IZH2 Q8N9T8 Q92879 Q9BY77	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7497
EIF4G1 EIF4G3 GATA3 HNRNPC KHDRBS3 NCBP1 NCBP2 PABPC1 PUF60 RBM39 SCAF4 SF3A2 SRSF9 U2AF2 XRN1	O43432 O75525 O95104 P07910 P11940 P23771 P26368 P52298 Q04637 Q09161 Q13242 Q14498 Q15428 Q8IZH2 Q9UHX1	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9381
EIF4G1 EIF4G3 HNRNPC KHDRBS3 NCBP1 NCBP2 PABPC1 PARS2 PUF60 RBM39 SCAF8 SF3A2 SRSF9 U2AF2 XRN1	O43432 O75525 P07910 P11940 P26368 P52298 Q04637 Q09161 Q13242 Q14498 Q15428 Q7L3T8 Q8IZH2 Q9UHX1 Q9UPN6	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3683
CDK9 CELF1 EIF4E EIF4G3 GAR1 H1-2 RBM39 RPS4X RPS8 SRSF1 UBC USP10 XRN1	O43432 P06730 P0CG48 P16403 P50750 P62241 P62701 Q07955 Q14498 Q14694 Q8IZH2 Q92879 Q9NY12	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3919

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	40595564

Sequence, Structure & Domains

Sequences

Length

1,706

Mass

194,107

Sequence

MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZH2-1; Sequence=Displayed; Name=2; IsoId=Q8IZH2-2; Sequence=VSP_016694, VSP_016695; Name=3; IsoId=Q8IZH2-3; Sequence=VSP_016692, VSP_016693

Alternative Sequence

449..459; DDFLADQAACY -> EYVFANAFILK (in isoform 3); 460..1706; Missing (in isoform 3); 1354; M -> MK (in isoform 2); 1540..1552; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1623..1642; Polar residues; 1647..1657; Low complexity; 1658..1676; Polar residues; 1677..1694; Basic residues

Region

1619..1706; Disordered

Protein Families

5'-3' exonuclease family

Sequence Similarities

Belongs to the 5'-3' exonuclease family.

Clinical Relevance

Disease Involvement

Tumor suppressor

Antibody

HPA035005 HPA035006

Interaction Protein

ENSG00000038358ENSG00000105193

Interaction Count

Interaction Dataset

intact_biogrid_opencellbiogrid_opencell