Protein detail

XRN1

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein symbol XRN1	UniProt ID Q8IZH2	EVMP score 0.63
Frequency 7	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

Basic Information

Protein Names

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein Class

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000114127

Entrez Gene Symbol

XRN1

Gene Synonym

SEP1

Gene Description

5'-3' exoribonuclease 1

Chromosome

Position

142306607-142448062

Frequency

EVMP Score

0.63

Fluorescence & Localization

Cell SpecificCardiomyocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M76 Pid p38 alpha beta pathway
M67 Pid arf6 trafficking pathway
M136 Pid foxo pathway

Mediation Categories

Clinical-translation mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

31 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CIRBP EIF4E EIF4G2 EIF4G3 FBL FUS HNRNPM NCBP1 PRMT1 SRSF2 TAF15 UBC XRN1	O43432 P06730 P0CG48 P22087 P35637 P52272 P78344 Q01130 Q09161 Q14011 Q8IZH2 Q92804 Q99873	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4520
PQBP1 PRPF8 RBM22 SART3 WBP11 WBP4 XRN1	O60828 O75554 Q15020 Q6P2Q9 Q8IZH2 Q9NW64 Q9Y2W2	0:0:0:0:0:0:0	hu.MAP
CDK12 EIF4G2 ELAVL4 EWSR1 FUS H2BC15 NCBP1 RBM39 SCAF4 SRSF1 SRSF2 UBC XRN1 YTHDC1	O95104 P0CG48 P26378 P35637 P78344 Q01130 Q01844 Q07955 Q09161 Q14498 Q8IZH2 Q96MU7 Q99877 Q9NYV4	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6696
DCP1A DCP1B DCP2 DDX6 DIS3L2 EDC3 LSM3 LSM4 LSM6 LSM7 LSM8 TIAL1 UBC UPF1 XRN1	O95777 P0CG48 P26196 P62310 P62312 Q01085 Q8IU60 Q8IYB7 Q8IZD4 Q8IZH2 Q92900 Q96F86 Q9NPI6 Q9UK45 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4699
DCP1A DCP1B DCP2 DDX6 EDC3 ERMP1 LSM3 LSM4 LSM6 LSM8 PATL1 PTGR3 UBC UPF1 XRN1	O95777 P0CG48 P26196 P62310 P62312 Q7Z2K6 Q86TB9 Q8IU60 Q8IZD4 Q8IZH2 Q8N4Q0 Q92900 Q96F86 Q9NPI6 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7441
DCP1A DCP1B DCP2 DDX6 EDC3 HSPA1L IARS2 LSM3 LSM4 LSM6 LSM8 PI4K2B UPF1 XRN1	O95777 P26196 P34931 P62310 P62312 Q8IU60 Q8IZD4 Q8IZH2 Q8TCG2 Q92900 Q96F86 Q9NPI6 Q9NSE4 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9198
DDX24 DIS3L EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 IMPDH2 MRPL4 SKIC2 UBC XRN1	P0CG48 P12268 Q01780 Q13868 Q15024 Q15477 Q5RKV6 Q8IZH2 Q8TF46 Q96B26 Q9BYD3 Q9GZR7 Q9NPD3 Q9NQT4 Q9Y3B2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7457
DIS3 DIS3L EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HEATR1 SKIC2 UBC XRN1	P0CG48 Q01780 Q06265 Q13868 Q15024 Q15477 Q5RKV6 Q8IZH2 Q8TF46 Q96B26 Q9H583 Q9NPD3 Q9NQT4 Q9Y2L1 Q9Y3B2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9326
C1D DIS3 DIS3L EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX SKIC2 XRN1	P42285 Q01780 Q06265 Q13868 Q13901 Q15024 Q15477 Q5RKV6 Q8IZH2 Q8TF46 Q96B26 Q9NPD3 Q9NQT4 Q9Y2L1 Q9Y3B2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7850
EXOSC1 EXOSC10 EXOSC8 MTREX UPF2 XRN1	P42285 Q01780 Q8IZH2 Q96B26 Q9HAU5 Q9Y3B2	1:1:1:1:1:1	CompleatCFinder	Compleat:HC4902

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	40595564

Sequence, Structure & Domains

Sequences

Length

1,706

Mass

194,107

Sequence

MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZH2-1; Sequence=Displayed; Name=2; IsoId=Q8IZH2-2; Sequence=VSP_016694, VSP_016695; Name=3; IsoId=Q8IZH2-3; Sequence=VSP_016692, VSP_016693

Alternative Sequence

449..459; DDFLADQAACY -> EYVFANAFILK (in isoform 3); 460..1706; Missing (in isoform 3); 1354; M -> MK (in isoform 2); 1540..1552; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1623..1642; Polar residues; 1647..1657; Low complexity; 1658..1676; Polar residues; 1677..1694; Basic residues

Region

1619..1706; Disordered

Protein Families

5'-3' exonuclease family

Sequence Similarities

Belongs to the 5'-3' exonuclease family.

Clinical Relevance

Disease Involvement

Tumor suppressor

Antibody

HPA035005 HPA035006

Interaction Protein

ENSG00000038358ENSG00000105193

Interaction Count

Interaction Dataset

intact_biogrid_opencellbiogrid_opencell