Protein detail

XRN1

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Entry name XRN1	UniProt ID Q8IZH2	EVMP confidence score 0.63
Supporting publications (n) 7	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000114127

Entrez Gene Symbol

XRN1

Gene Synonym

SEP1

Gene Description

5'-3' exoribonuclease 1

Chromosome

Position

142306607-142448062

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization2

Cell SpecificCardiomyocytes

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (10)

Canonical Pathways (3)

M76 Pid p38 alpha beta pathway
M67 Pid arf6 trafficking pathway
M136 Pid foxo pathway

Mediation Categories

Clinical-translation mediation

Relations & Evidence36

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (31)

31 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	XRN1	Q8IZH2	2	PDB	PDB:9e70

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	40595564

Sequence, Structure & Domains10

Sequences

Length

1,706

Mass

194,107

Sequence

MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZH2-1; Sequence=Displayed; Name=2; IsoId=Q8IZH2-2; Sequence=VSP_016694, VSP_016695; Name=3; IsoId=Q8IZH2-3; Sequence=VSP_016692, VSP_016693

Alternative Sequence

449..459; DDFLADQAACY -> EYVFANAFILK (in isoform 3); 460..1706; Missing (in isoform 3); 1354; M -> MK (in isoform 2); 1540..1552; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1623..1642; Polar residues; 1647..1657; Low complexity; 1658..1676; Polar residues; 1677..1694; Basic residues

Region

1619..1706; Disordered

Protein Families

5'-3' exonuclease family

Sequence Similarities

Belongs to the 5'-3' exonuclease family.

Clinical Relevance5

Disease Involvement

Tumor suppressor

Antibody (2)

HPA035005 HPA035006

Interaction Protein (2)

ENSG00000038358ENSG00000105193

Interaction Count

Interaction Dataset (2)

intact_biogrid_opencellbiogrid_opencell

Supporting Publications7

PMID	Title	Abstract
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39948040	Quantitative proteomics identifies possible flow of metastatic cues between progressive stages of colorectal cancer via transfer of ceramide-dependent exosomal cargoes.	No abstract available