Protein detail

NLGNX

Neuroligin-4, X-linked (Neuroligin X) (HNLX)

Protein symbol NLGNX	UniProt ID Q8N0W4	EVMP score 0.25
Frequency 2	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Neuroligin-4, X-linked (Neuroligin X) (HNLX)

Protein Class

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

677..697; Helical

Transmembrane Count

Ensembl

ENSG00000146938

Entrez Gene Symbol

NLGN4X

Gene Synonym

HLNXKIAA1260NLGNNLGN4

Gene Description

Neuroligin 4 X-linked

Chromosome

Position

5840637-6228867

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificExtravillous trophoblasts

Function & Pathway

Protein Function

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NLGN4X	PRKCA	P17252	T	707	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
neuroligin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NLGNX	Q8N0W4	NRX1A	Q9ULB1	Yes	Yes	No	CellPhoneDBSIGNORconnectomeDB2020	SIGNOR:18923512 connectomeDB2020:20543817
NLGNX	Q8N0W4	NRX1B	P58400	Yes	Yes	No	CellPhoneDBSIGNORconnectomeDB2020	SIGNOR:18923512 connectomeDB2020:20543817
NLGNX	Q8N0W4	NRX2A	Q9P2S2	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	NRX2B	P58401	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	NRX3B	Q9HDB5	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	NRX3A	Q9Y4C0	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	DLG4	P78352	Yes	Yes	No	HPRDSIGNOR	HPRD:11368788 SIGNOR:18923512
KPCA	P17252	NLGNX	Q8N0W4	Yes	No	No	iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:25675530

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NLGN4X	Q8N0W4	2	PDB	PDB:3be8

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

816

Mass

91,915

Sequence

MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N0W4-1; Sequence=Displayed; Name=2; IsoId=Q8N0W4-2; Sequence=VSP_013270

Alternative Sequence

157; D -> DGANTKKNADDITSNDRGEDE (in isoform 2)

3D Structural Models

Turn

116..118; 176..178; 270..272; 286..288; 373..376; 381..383; 489..492; 564..566

Helix

84..86; 119..122; 128..134; 136..140; 182..184; 188..194; 206..210; 222..237; 238..241; 255..263; 267..269; 293..303; 311..319; 323..327; 353..358; 361..364; 377..380; 392..406; 413..423; 433..448; 450..461; 493..496; 499..501; 514..533; 584..591; 594..596

Beta Strand

47..50; 53..56; 58..60; 70..77; 98..102; 148..154; 166..172; 197..201; 243..253; 274..280; 283..285; 339..341; 346..349; 365..372; 410..412; 467..472; 478..481; 505..507; 568..575; 577..581

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

649..658; Basic and acidic residues

Region

359..364; Interaction with NRXN1; 636..659; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance

Disease Involvement

Asperger syndromeAutismAutism spectrum disorder

Antibody

HPA001651