Protein detail

NLGNX

Neuroligin-4, X-linked (Neuroligin X) (HNLX)

Entry name NLGNX	UniProt ID Q8N0W4	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Neuroligin-4, X-linked (Neuroligin X) (HNLX)

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

677..697; Helical

Transmembrane Count

Ensembl

ENSG00000146938

Entrez Gene Symbol

NLGN4X

Gene Synonym (4)

HLNXKIAA1260NLGNNLGN4

Gene Description

Neuroligin 4 X-linked

Chromosome

Position

5840637-6228867

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Cell SpecificExtravillous trophoblasts

Function & Pathway7

Protein Function (5)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (13)

Page 1 of 2

Molecular Function (7)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence54

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NLGN4X	PRKCA	P17252	T	707	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No

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Regulatory Interaction Network (8)

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NLGNX	Q8N0W4	NRX1A	Q9ULB1	Yes	Yes	No	CellPhoneDBSIGNORconnectomeDB2020	SIGNOR:18923512 connectomeDB2020:20543817
NLGNX	Q8N0W4	NRX1B	P58400	Yes	Yes	No	CellPhoneDBSIGNORconnectomeDB2020	SIGNOR:18923512 connectomeDB2020:20543817
NLGNX	Q8N0W4	NRX2A	Q9P2S2	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	NRX2B	P58401	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	NRX3B	Q9HDB5	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	NRX3A	Q9Y4C0	Yes	Yes	No	CellPhoneDBSIGNOR	SIGNOR:18923512
NLGNX	Q8N0W4	DLG4	P78352	Yes	Yes	No	HPRDSIGNOR	HPRD:11368788 SIGNOR:18923512
KPCA	P17252	NLGNX	Q8N0W4	Yes	No	No	iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:25675530

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NLGN4X	Q8N0W4	2	PDB	PDB:3be8

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains13

Sequences

Length

816

Mass

91,915

Sequence

MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N0W4-1; Sequence=Displayed; Name=2; IsoId=Q8N0W4-2; Sequence=VSP_013270

Alternative Sequence

157; D -> DGANTKKNADDITSNDRGEDE (in isoform 2)

3D Structural Models

Turn

116..118; 176..178; 270..272; 286..288; 373..376; 381..383; 489..492; 564..566

Helix

84..86; 119..122; 128..134; 136..140; 182..184; 188..194; 206..210; 222..237; 238..241; 255..263; 267..269; 293..303; 311..319; 323..327; 353..358; 361..364; 377..380; 392..406; 413..423; 433..448; 450..461; 493..496; 499..501; 514..533; 584..591; 594..596

Beta Strand

47..50; 53..56; 58..60; 70..77; 98..102; 148..154; 166..172; 197..201; 243..253; 274..280; 283..285; 339..341; 346..349; 365..372; 410..412; 467..472; 478..481; 505..507; 568..575; 577..581

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

649..658; Basic and acidic residues

Region

359..364; Interaction with NRXN1; 636..659; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance2

Disease Involvement (3)

Asperger syndromeAutismAutism spectrum disorder

Antibody

HPA001651

Supporting Publications2

PMID	Title	Abstract
25755179	Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease.	No abstract available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available