Protein detail

GAPT

Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane)

Entry name GAPT	UniProt ID Q8N292	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Transmembrane

11..31; Helical

Transmembrane Count

Ensembl

ENSG00000175857

Entrez Gene Symbol

GAPT

Gene Synonym (2)

C5orf29FLJ33641

Gene Description

GRB2 binding adaptor protein, transmembrane

Chromosome

Position

58491435-58497090

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificlungCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway4

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Biological Process (3)

Mediation Categories

Immune mediation

Relations & Evidence17

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry [MALDI TOF]Mass spectrometryMass spectrometry\|Western blottingMass spectrometry [QTOF]	3	39408670 39408670 40596376

Sequence, Structure & Domains6

Sequences

Length

157

Mass

17,883

Sequence

MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY

Domain & Motif Annotations

Region

78..108; Disordered

Protein Families

GAPT family

Sequence Similarities

Belongs to the GAPT family.

Clinical Relevance1

Antibody (2)

HPA011048 HPA011070

Supporting Publications1

PMID	Title	Abstract
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available