Protein detail

GAPT

Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane)

Protein symbol GAPT	UniProt ID Q8N292	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein GAPT (GRB2-binding adapter protein, transmembrane) (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Transmembrane

11..31; Helical

Transmembrane Count

Ensembl

ENSG00000175857

Entrez Gene Symbol

GAPT

Gene Synonym

C5orf29FLJ33641

Gene Description

GRB2 binding adaptor protein, transmembrane

Chromosome

Position

58491435-58497090

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificlungCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Biological Process

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry [MALDI TOF]Mass spectrometryMass spectrometry\|Western blottingMass spectrometry [QTOF]	3	39408670 39408670 40596376

Sequence, Structure & Domains

Sequences

Length

157

Mass

17,883

Sequence

MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY

3D Structural Models

Domain & Motif Annotations

Region

78..108; Disordered

Protein Families

GAPT family

Sequence Similarities

Belongs to the GAPT family.

Clinical Relevance

Antibody

HPA011048 HPA011070