Protein detail

TOR2X

Prosalusin (Torsin family 2 member A) (Torsin-2A) [Cleaved into: Salusin-alpha; Salusin-beta]

Protein symbol TOR2X	UniProt ID Q8N2E6	EVMP score 0.50
Frequency 6	Transmembrane count	Protein classification Predicted secreted proteins

Basic Information

Protein Names

Prosalusin (Torsin family 2 member A) (Torsin-2A) [Cleaved into: Salusin-alpha; Salusin-beta]

Protein Class

Predicted secreted proteins

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000160404

Entrez Gene Symbol

TOR2A

Gene Synonym

FLJ14771TORP1

Gene Description

Torsin family 2 member A

Chromosome

Position

127731524-127735313

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

30 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	connectomeDB2020	No	No	Yes	No	No
secreted	secreted	connectomeDB2020	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
ligand	ligand	connectomeDB2020	Yes	No	Yes	No	No
ligand	ligand	connectomeDB2020	Yes	No	Yes	No	No
prosalusin	ligand	OmniPath	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster128	DNAJC3 MANBA TOR1A TOR1B TOR2A TOR3A TOR4A	O00462 O14656 O14657 Q13217 Q8N2E6 Q9H497 Q9NXH8	1:1:1:1:1:1:1	Compleat	Compleat:HC3203	22036573
	CENPB TOR1A TOR2A ZNF707	O14656 P07199 Q5JU69 Q96C28	0:0:0:0	hu.MAP2
	CENPB TOR1A TOR2A ZNF707 ZNF747	O14656 P07199 Q5JU69 Q96C28 Q9BV97	0:0:0:0:0	hu.MAP2
	CENPB TOR1A TOR2A ZNF707	O14656 P07199 Q8N2E6 Q96C28	0:0:0:0	hu.MAP2
	CENPB TOR1A TOR2A ZNF707 ZNF747	O14656 P07199 Q8N2E6 Q96C28 Q9BV97	0:0:0:0:0	hu.MAP2
	TOR1A TOR2A	O14656 Q5JU69	0:0	hu.MAP
	TOR1A TOR2A	O14656 Q8N2E6	0:0	hu.MAP
	TOR2A ZNF707	Q5JU69 Q96C28	0:0	hu.MAP2
	TOR2A ZNF707	Q8N2E6 Q96C28	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	5	32795414 33035814 30646616 38321535 32089743

Sequence, Structure & Domains

Sequences

Length

242

Mass

26,262

Sequence

MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGSSWVVYGTNYRKAIFIFIRWLLKLGHHGRAPPRRSGALPPAPAAPRPALRAQRAGPAGPGAKG

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q8N2E6-1; Sequence=Displayed; Name=1; IsoId=Q5JU69-1; Sequence=External; Name=2; IsoId=Q5JU69-2; Sequence=External; Name=3; IsoId=Q5JU69-5; Sequence=External

3D Structural Models

Domain & Motif Annotations

Compositional Bias

225..235; Low complexity

Region

210..242; Disordered

Protein Families

ClpA/ClpB family
Torsin subfamily

Sequence Similarities

Belongs to the ClpA/ClpB family. Torsin subfamily.

Clinical Relevance

Antibody

HPA071229