Protein detail
LAT4
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
Entry name LAT4 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
20..40; Helical; 90..110; Helical; 120..140; Helical; 143..163; Helical; 177..197; Helical; 203..223; Helical; 323..345; Helical; 365..385; Helical; 435..455; Helical; 462..482; Helical; 490..510; Helical; 516..536; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC34680
Gene Description
Solute carrier family 43 member 2
Chromosome
17
Position
1569268-1628886
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway6
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (2)
Molecular Function (8)
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015175 neutral L-amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015188 L-isoleucine transmembrane transporter activity
- GO:0015190 L-leucine transmembrane transporter activity
- GO:0015191 L-methionine transmembrane transporter activity
- GO:0015192 L-phenylalanine transmembrane transporter activity
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence22
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slc43 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Sequence, Structure & Domains8
Sequences
Length
569
Mass
62,747
Sequence
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N370-1; Sequence=Displayed; Name=2; IsoId=Q8N370-2; Sequence=VSP_028665, VSP_028666; Name=3; IsoId=Q8N370-3; Sequence=VSP_028664; Name=4; IsoId=Q8N370-4; Sequence=VSP_055373, VSP_055374
Alternative Sequence
1..30; MAPTLATAHRRRWWMACTAVLENLLFSAVL -> MTYGSPQANASPSDAVALDHGEVSRRQQQE (in isoform 4); 31..167; Missing (in isoform 4); 358; K -> KTVMA (in isoform 3); 407..489; GEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQS -> CVGRAGAPAPSPQPLQKDPRAACQAQGGWDRGREQCTPAPPGALRETHSFSSACVSTAPLFMEIVWNAMEMLKFEARCGDSCL (in isoform 2); 490..569; Missing (in isoform 2)
Domain & Motif Annotations
Region
395..416; Disordered
Protein Families
SLC43A transporter (TC 2.A.1.44) family
Sequence Similarities
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Clinical Relevance1
Antibody