Protein detail
LAT4
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
Protein symbol LAT4 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
20..40; Helical; 90..110; Helical; 120..140; Helical; 143..163; Helical; 177..197; Helical; 203..223; Helical; 323..345; Helical; 365..385; Helical; 435..455; Helical; 462..482; Helical; 490..510; Helical; 516..536; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC34680
Gene Description
Solute carrier family 43 member 2
Chromosome
17
Position
1569268-1628886
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015175 neutral L-amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015188 L-isoleucine transmembrane transporter activity
- GO:0015190 L-leucine transmembrane transporter activity
- GO:0015191 L-methionine transmembrane transporter activity
- GO:0015192 L-phenylalanine transmembrane transporter activity
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
569
Mass
62,747
Sequence
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N370-1; Sequence=Displayed; Name=2; IsoId=Q8N370-2; Sequence=VSP_028665, VSP_028666; Name=3; IsoId=Q8N370-3; Sequence=VSP_028664; Name=4; IsoId=Q8N370-4; Sequence=VSP_055373, VSP_055374
Alternative Sequence
1..30; MAPTLATAHRRRWWMACTAVLENLLFSAVL -> MTYGSPQANASPSDAVALDHGEVSRRQQQE (in isoform 4); 31..167; Missing (in isoform 4); 358; K -> KTVMA (in isoform 3); 407..489; GEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQS -> CVGRAGAPAPSPQPLQKDPRAACQAQGGWDRGREQCTPAPPGALRETHSFSSACVSTAPLFMEIVWNAMEMLKFEARCGDSCL (in isoform 2); 490..569; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Region
395..416; Disordered
Protein Families
SLC43A transporter (TC 2.A.1.44) family
Sequence Similarities
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Clinical Relevance
Antibody