Protein detail

PALS1

Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)

Entry name PALS1	UniProt ID Q8N3R9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000072415

Entrez Gene Symbol

PALS1

Gene Synonym (2)

FLJ12615MPP5

Gene Description

Protein associated with LIN7 1, MAGUK p55 family member

Chromosome

Position

67240713-67336061

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (15)

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Molecular Function (4)

Biological Process (3)

KEGG (4)

Reactome (11)

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Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence20

Ligand-Receptor Signaling (13)

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	Ramilowski_location	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No
maguk_tight_junction	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

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Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CRB1-MPP5-INADL complex	CRB1 PALS1 PATJ	P82279 Q8N3R9 Q8NI35	1:1:1	CORUMCompleatComplexPortal	Compleat:HC2419CORUM:460	28424578 14755292 11927608 32411799
CRB3-PALS1-PATJ cell polarity complex	CRB3 MPDZ PALS1 PATJ	O75970 Q8N3R9 Q8NI35 Q9BUF7	1:1:1:1	Compleat	Compleat:HC761	12527193
CRUMBS3-PALS1-PATJ cell polarity complex	CRB3 PALS1 PATJ	Q8N3R9 Q8NI35 Q9BUF7	1:1:1	ComplexPortal	intact:EBI-25828047	16129888 14755292 19625503 32411799
MPP4-MPP5-CRB1 complex	CRB1 MPP4 PALS1	P82279 Q8N3R9 Q96JB8	1:1:1	CompleatCORUM	Compleat:HC3321CORUM:461	15914641
	AMOTL1 AMOTL2 CRB3 PALS1 TEAD3 YAP1	P46937 Q8IY63 Q8N3R9 Q99594 Q9BUF7 Q9Y2J4	0:0:0:0:0:0	hu.MAP2
	CRB1 PALS1	P82279 Q8N3R9	1:1	PDB	PDB:4uu5

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	2	38731868 26801919

Sequence, Structure & Domains15

Sequences

Length

675

Mass

77,294

Sequence

MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N3R9-1; Sequence=Displayed; Name=2; IsoId=Q8N3R9-2; Sequence=VSP_014002

Alternative Sequence

1..34; Missing (in isoform 2)

3D Structural Models

Turn

198..200; 488..491; 503..506; 524..527; 568..570; 661..664

Helix

124..137; 141..155; 157..173; 186..197; 203..213; 215..229; 288..292; 314..322; 358..360; 367..369; 492..502; 533..541; 560..567; 579..581; 582..586; 602..608; 621..631; 634..636; 648..660; 671..673

Beta Strand

230..232; 249..251; 255..261; 268..274; 277..283; 300..304; 326..333; 348..352; 378..383; 389..394; 405..408; 464..472; 482..486; 545..551; 554..559; 571..576; 593..598; 639..644; 667..670

3D Structure

Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (7)

Domain & Motif Annotations

Compositional Bias

10..34; Basic and acidic residues; 54..78; Basic and acidic residues

Domain (CC)

The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ.; DOMAIN: The PDZ domain binds to the C-terminus of SC6A1..

Domain (FT)

120..177; L27 1; 179..235; L27 2; 256..336; PDZ; 345..417; SH3; 479..660; Guanylate kinase-like

Region

1..345; Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions; 1..34; Disordered; 21..140; Interaction with PARD6B; 51..78; Disordered; 181..243; Interaction with LIN7C

Protein Families

MAGUK family

Sequence Similarities

Belongs to the MAGUK family.

Clinical Relevance4

Antibody (2)

HPA000993 HPA063890

Interaction Protein (6)

ENSG00000077549ENSG00000104863ENSG00000111052ENSG00000130545ENSG00000132849ENSG00000148943

Interaction Count

Interaction Dataset (4)

biogrid_opencellintact_biogrid_bioplexintact_biogridbiogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available