Protein detail
PALS1
Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
Entry name PALS1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ12615MPP5
Gene Description
Protein associated with LIN7 1, MAGUK p55 family member
Chromosome
14
Position
67240713-67336061
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0005923 bicellular tight junction
- GO:0016324 apical plasma membrane
- GO:0030424 axon
- GO:0032991 protein-containing complex
- GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
- GO:0035749 myelin sheath adaxonal region
- GO:0043204 perikaryon
- GO:0043219 lateral loop
- GO:0043220 Schmidt-Lanterman incisure
- GO:0043296 apical junction complex
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-5663205 infectious disease
- R-hsa-9692914 sars cov 1 host interactions
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9705683 sars cov 2 host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9705677 sars cov 2 targets pdz proteins in cell cell junction
- R-hsa-9679506 sars cov infections
- R-hsa-420029 tight junction interactions
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CRB1-MPP5-INADL complex | CRB1PALS1PATJ | P82279Q8N3R9Q8NI35 | 1:1:1 | CORUMCompleatComplexPortal | Compleat:HC2419CORUM:460 | 28424578147552921192760832411799 |
| CRB3-PALS1-PATJ cell polarity complex | CRB3MPDZPALS1PATJ | O75970Q8N3R9Q8NI35Q9BUF7 | 1:1:1:1 | Compleat | Compleat:HC761 | 12527193 |
| CRUMBS3-PALS1-PATJ cell polarity complex | CRB3PALS1PATJ | Q8N3R9Q8NI35Q9BUF7 | 1:1:1 | ComplexPortal | intact:EBI-25828047 | 16129888147552921962550332411799 |
| MPP4-MPP5-CRB1 complex | CRB1MPP4PALS1 | P82279Q8N3R9Q96JB8 | 1:1:1 | CompleatCORUM | Compleat:HC3321CORUM:461 | 15914641 |
| AMOTL1AMOTL2CRB3PALS1TEAD3YAP1 | P46937Q8IY63Q8N3R9Q99594Q9BUF7Q9Y2J4 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CRB1PALS1 | P82279Q8N3R9 | 1:1 | PDB | PDB:4uu5 |
Sequence, Structure & Domains
Sequences
Length
675
Mass
77,294
Sequence
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N3R9-1; Sequence=Displayed; Name=2; IsoId=Q8N3R9-2; Sequence=VSP_014002
Alternative Sequence
1..34; Missing (in isoform 2)
3D Structural Models
Turn
198..200; 488..491; 503..506; 524..527; 568..570; 661..664
Helix
124..137; 141..155; 157..173; 186..197; 203..213; 215..229; 288..292; 314..322; 358..360; 367..369; 492..502; 533..541; 560..567; 579..581; 582..586; 602..608; 621..631; 634..636; 648..660; 671..673
Beta Strand
230..232; 249..251; 255..261; 268..274; 277..283; 300..304; 326..333; 348..352; 378..383; 389..394; 405..408; 464..472; 482..486; 545..551; 554..559; 571..576; 593..598; 639..644; 667..670
3D Structure
Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
10..34; Basic and acidic residues; 54..78; Basic and acidic residues
Domain (CC)
The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ.; DOMAIN: The PDZ domain binds to the C-terminus of SC6A1..
Domain (FT)
120..177; L27 1; 179..235; L27 2; 256..336; PDZ; 345..417; SH3; 479..660; Guanylate kinase-like
Region
1..345; Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions; 1..34; Disordered; 21..140; Interaction with PARD6B; 51..78; Disordered; 181..243; Interaction with LIN7C
Protein Families
MAGUK family
Sequence Similarities
Belongs to the MAGUK family.