Protein detail
CLD19
Claudin-19
Protein symbol CLD19 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 4 | Protein classification |
Basic Information
Protein Names
Claudin-19
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Transmembrane
8..28; Helical; 82..102; Helical; 118..138; Helical; 161..181; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificConjunctival goblet cellsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Cellular Component
- GO:0005634 nucleus
- GO:0005886 plasma membrane
- GO:0005923 bicellular tight junction
- GO:0016323 basolateral plasma membrane
- GO:0033010 paranodal junction
- GO:0043220 Schmidt-Lanterman incisure
- GO:0043296 apical junction complex
- GO:0048471 perinuclear region of cytoplasm
- GO:0070160 tight junction
- GO:0097453 mesaxon
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M64 Pid s1p s1p4 pathway
- M120 Pid arf6 downstream pathway
- M138 Pid thrombin par4 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| tight_junction | tight_junction | HGNC | Yes | Yes | No | No | No |
| claudin | tight_junction | Almen2009 | Yes | Yes | No | No | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
224
Mass
23,229
Sequence
MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREPVVKLPASAKGPLGV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N6F1-1; Sequence=Displayed; Name=2; IsoId=Q8N6F1-2; Sequence=VSP_010342; Name=3; IsoId=Q8N6F1-3; Sequence=VSP_044839
Alternative Sequence
131..224; LCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREPVVKLPASAKGPLGV -> MNLAQPCSWAGPQLAWPCWAAPSSAAHARSQRDPTAAHSPIGLDPLLLPESTSELRLPWPAPHPVAPLPSIQPASQHPGQGHWGIGWA (in isoform 3); 210..224; PVVKLPASAKGPLGV -> YV (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Region
191..224; Disordered
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.