Protein detail

TMC5A

Transmembrane and coiled-coil domain-containing protein 5A

Entry name TMC5A	UniProt ID Q8N6Q1	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane and coiled-coil domain-containing protein 5A

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

224..244; Helical

Transmembrane Count

Ensembl

ENSG00000166069

Entrez Gene Symbol

TMCO5A

Gene Synonym (2)

MGC35118TMCO5

Gene Description

Transmembrane and coiled-coil domains 5A

Chromosome

Position

37921939-37967724

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence15

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	4	39409015 38731868 40098346 37922300

Sequence, Structure & Domains8

Sequences

Length

288

Mass

34,174

Sequence

MEISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQETLKKIEEELEALFLEREVSKLVSMNPVEKEHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLSYMFFHVRFINPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLPH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N6Q1-1; Sequence=Displayed; Name=2; IsoId=Q8N6Q1-2; Sequence=VSP_028246, VSP_028247

Alternative Sequence

224..228; IFCCL -> WASSF (in isoform 2); 229..288; Missing (in isoform 2)

Domain & Motif Annotations

Coiled Coil

10..192

Protein Families

TMCO5 family

Sequence Similarities

Belongs to the TMCO5 family.

Clinical Relevance1

Antibody (2)

HPA056530 HPA064017

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available