Protein detail

S43A3

Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3)

Entry name S43A3	UniProt ID Q8NBI5	EVMP confidence score 0.60
Supporting publications (n) 13	Transmembrane count 12	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Transmembrane

17..37; Helical; 72..92; Helical; 102..122; Helical; 123..143; Helical; 156..176; Helical; 188..208; Helical; 279..299; Helical; 319..339; Helical; 356..376; Helical; 396..418; Helical; 427..447; Helical; 456..476; Helical

Transmembrane Count

Ensembl

ENSG00000134802

Entrez Gene Symbol

SLC43A3

Gene Synonym (5)

DKFZp762A227Eeg1FOAP-13PRO1659SEEEG-1

Gene Description

Solute carrier family 43 member 3

Chromosome

Position

57406954-57427580

Supporting publications (n)

EVMP confidence score

0.60

Function & Pathway4

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Cellular Component

GO:0016323 basolateral plasma membrane

Molecular Function (5)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence22

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
basolateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	4	31508500 33709510 37922300 33709510

Sequence, Structure & Domains7

Sequences

Length

491

Mass

54,529

Sequence

MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSAGSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYGLCPGNGTTKEEKETAEHENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAVALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHPFLVYRECRTWKESPSAIA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NBI5-1; Sequence=Displayed; Name=2; IsoId=Q8NBI5-2; Sequence=VSP_055620

Alternative Sequence

61; A -> AGRLGCMGDLFSTP (in isoform 2)

Domain & Motif Annotations

Protein Families

SLC43A transporter (TC 2.A.1.44) family

Sequence Similarities

Belongs to the SLC43A transporter (TC 2.A.1.44) family.

Clinical Relevance4

Antibody (2)

HPA030551 HPA077244

Interaction Protein

ENSG00000165280

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications13

PMID	Title	Abstract
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	No abstract available
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
30408591	Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease.	No abstract available
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No abstract available
33204424	Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
37205098	Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers.	No abstract available

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