Protein detail

DGLB

Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)

Protein symbol
DGLB
UniProt ID
Q8NCG7
EVMP score
0.50
Frequency
1
Transmembrane count
4
Protein classification
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
Protein Function
  • Enzymes
  • ENZYME proteins:Hydrolases
Transmembrane
18..38; Helical; 59..79; Helical; 103..123; Helical; 133..153; Helical
Transmembrane Count
4
Ensembl
ENSG00000164535
Entrez Gene Symbol
DAGLB
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificbasophil
Function & Pathway
Protein Function
  • Enzymes
  • ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

19 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
extracellularextracellularOmniPathNoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_surface_ligandcell_surface_ligandCellPhoneDBYesNoNoNoNo
cell_surface_ligandcell_surface_ligandOmniPathYesNoNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
2arachidonoylglycerol_byDAGLBDAGLBQ8NCG71CellPhoneDBCellChatDBCellPhoneDB:2arachidonoylglycerol_byDAGLB
CHPT1DAGLBTMEM171Q8NCG7Q8WUD6Q8WVE60:0:0hu.MAP2
CHPT1DAGLBTMEM171TPCN1Q8NCG7Q8WUD6Q8WVE6Q9ULQ10:0:0:0hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry130550287
Sequence, Structure & Domains

Sequences

Length
672
Mass
73,732
Sequence
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NCG7-1; Sequence=Displayed; Name=2; IsoId=Q8NCG7-2; Sequence=VSP_020245; Name=3; IsoId=Q8NCG7-3; Sequence=VSP_020246, VSP_020247; Name=4; IsoId=Q8NCG7-4; Sequence=VSP_043309
Alternative Sequence
1..281; Missing (in isoform 2); 140..310; SWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDC -> RTQIWCPATLRRASPCFISNRTISGTTKSLPRWSAMPQGAPS (in isoform 4); 249..267; IRNNQEPAQVVCHAPGSSQ -> TRATGNCPRNDGLTLLSLN (in isoform 3); 268..672; Missing (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Protein Families
  • AB hydrolase superfamily
  • Lipase family
Sequence Similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Clinical Relevance
Drugs
ORLISTAT