Protein detail

DGLB

Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)

Entry name
DGLB
UniProt ID
Q8NCG7
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
4
Protein classification
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information8
Protein Names
Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
Protein Function (2)
  • Enzymes
  • ENZYME proteins:Hydrolases
Transmembrane
18..38; Helical; 59..79; Helical; 103..123; Helical; 133..153; Helical
Transmembrane Count
4
Ensembl
ENSG00000164535
Entrez Gene Symbol
DAGLB
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecificplacentaCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificbasophil
Function & Pathway7
Protein Function (2)
  • Enzymes
  • ENZYME proteins:Hydrolases
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (2)
Reactome (6)
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence23

Ligand-Receptor Signaling (19)

19 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
extracellularextracellularOmniPathNoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_surface_ligandcell_surface_ligandCellPhoneDBYesNoNoNoNo
cell_surface_ligandcell_surface_ligandOmniPathYesNoNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
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Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
2arachidonoylglycerol_byDAGLBDAGLBQ8NCG71CellPhoneDBCellChatDBCellPhoneDB:2arachidonoylglycerol_byDAGLB
CHPT1DAGLBTMEM171Q8NCG7Q8WUD6Q8WVE60:0:0hu.MAP2
CHPT1DAGLBTMEM171TPCN1Q8NCG7Q8WUD6Q8WVE6Q9ULQ10:0:0:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry130550287
Sequence, Structure & Domains7

Sequences

Length
672
Mass
73,732
Sequence
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NCG7-1; Sequence=Displayed; Name=2; IsoId=Q8NCG7-2; Sequence=VSP_020245; Name=3; IsoId=Q8NCG7-3; Sequence=VSP_020246, VSP_020247; Name=4; IsoId=Q8NCG7-4; Sequence=VSP_043309
Alternative Sequence
1..281; Missing (in isoform 2); 140..310; SWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDC -> RTQIWCPATLRRASPCFISNRTISGTTKSLPRWSAMPQGAPS (in isoform 4); 249..267; IRNNQEPAQVVCHAPGSSQ -> TRATGNCPRNDGLTLLSLN (in isoform 3); 268..672; Missing (in isoform 3)

Domain & Motif Annotations

Protein Families (2)
  • AB hydrolase superfamily
  • Lipase family
Sequence Similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Clinical Relevance1
Drugs
ORLISTAT
Supporting Publications1
PMIDTitleAbstract
27487081Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.No abstract available