Protein detail
DGLB
Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
Entry name DGLB | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
Protein Function (2)
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
18..38; Helical; 59..79; Helical; 103..123; Helical; 133..153; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecificplacentaCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificbasophil
Function & Pathway7
Protein Function (2)
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (2)
Reactome (6)
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence23
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| 2arachidonoylglycerol_byDAGLB | DAGLB | Q8NCG7 | 1 | CellPhoneDBCellChatDB | CellPhoneDB:2arachidonoylglycerol_byDAGLB | |
| CHPT1DAGLBTMEM171 | Q8NCG7Q8WUD6Q8WVE6 | 0:0:0 | hu.MAP2 | |||
| CHPT1DAGLBTMEM171TPCN1 | Q8NCG7Q8WUD6Q8WVE6Q9ULQ1 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains7
Sequences
Length
672
Mass
73,732
Sequence
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NCG7-1; Sequence=Displayed; Name=2; IsoId=Q8NCG7-2; Sequence=VSP_020245; Name=3; IsoId=Q8NCG7-3; Sequence=VSP_020246, VSP_020247; Name=4; IsoId=Q8NCG7-4; Sequence=VSP_043309
Alternative Sequence
1..281; Missing (in isoform 2); 140..310; SWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDC -> RTQIWCPATLRRASPCFISNRTISGTTKSLPRWSAMPQGAPS (in isoform 4); 249..267; IRNNQEPAQVVCHAPGSSQ -> TRATGNCPRNDGLTLLSLN (in isoform 3); 268..672; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families (2)
- AB hydrolase superfamily
- Lipase family
Sequence Similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Clinical Relevance1
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27487081 | Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation. | No abstract available |