Protein detail

CNNM3

Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)

Entry name CNNM3	UniProt ID Q8NE01	EVMP score 0.38
Frequency 8	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

11..27; Helical; 193..213; Helical; 221..241; Helical; 261..281; Helical

Transmembrane Count

Ensembl

ENSG00000168763

Entrez Gene Symbol

CNNM3

Gene Synonym

ACDP3

Gene Description

Cyclin and CBS domain divalent metal cation transport mediator 3

Chromosome

Position

96816245-96835382

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cellBlood Cell Specificplasmacytoid DC

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CNNM3 PTP4A3	O75365 Q8NE01	2:2	PDB	PDB:5tsr
CNNM3 PTP4A2	Q12974 Q8NE01	1:1	PDB	PDB:5k25PDB:6wurPDB:5k22PDB:5k23
CNNM3	Q8NE01	2	PDB	PDB:6mn6PDB:6dfd

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	33709510 37922300

Sequence, Structure & Domains

Sequences

Length

707

Mass

76,119

Sequence

MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAAGAGWVRGGAARDTPDATFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLRLRLRAEAVRPHSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESEDYRDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPGVPVEGSPGRNPGV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NE01-1; Sequence=Displayed; Name=2; IsoId=Q8NE01-2; Sequence=VSP_027082; Name=3; IsoId=Q8NE01-3; Sequence=VSP_027082, VSP_027083

Alternative Sequence

410..457; Missing (in isoform 2 and isoform 3); 694..707; GVPVEGSPGRNPGV -> SLPLLPRGRDSAAYSDSDLFGLSHLVSAVTAFVWP (in isoform 3)

3D Structural Models

Turn

302..308; 309..311; 452..454; 513..515; 571..574

Helix

314..316; 321..323; 335..342; 365..368; 379..385; 399..407; 437..445; 494..507; 509..511; 518..525; 528..530; 544..546; 587..590; 643..654

Beta Strand

318..320; 347..355; 359..364; 373..375; 392..394; 412..420; 423..425; 428..436; 531..534; 538..540; 547..549; 557..563; 566..570; 575..579; 627..634; 636..642

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Compositional Bias

678..691; Polar residues

Domain (FT)

130..308; CNNM transmembrane; 318..379; CBS 1; 386..452; CBS 2

Region

678..707; Disordered

Protein Families

ACDP family

Sequence Similarities

Belongs to the ACDP family.

Clinical Relevance

Antibody

HPA016711

Interaction Protein

ENSG00000127022ENSG00000184007

Interaction Count

Interaction Dataset

biogrid_opencellintact_biogrid