Protein detail

CNNM3

Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)

Entry name CNNM3	UniProt ID Q8NE01	EVMP score 0.38
Frequency 8	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

11..27; Helical; 193..213; Helical; 221..241; Helical; 261..281; Helical

Transmembrane Count

Ensembl

ENSG00000168763

Entrez Gene Symbol

CNNM3

Gene Synonym

ACDP3

Gene Description

Cyclin and CBS domain divalent metal cation transport mediator 3

Chromosome

Position

96816245-96835382

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cellBlood Cell Specificplasmacytoid DC

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CNNM3 PTP4A3	O75365 Q8NE01	2:2	PDB	PDB:5tsr
CNNM3 PTP4A2	Q12974 Q8NE01	1:1	PDB	PDB:5k25PDB:6wurPDB:5k22PDB:5k23
CNNM3	Q8NE01	2	PDB	PDB:6mn6PDB:6dfd

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	33709510 37922300

Sequence, Structure & Domains

Sequences

Length

707

Mass

76,119

Sequence

MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAAGAGWVRGGAARDTPDATFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLRLRLRAEAVRPHSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESEDYRDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPGVPVEGSPGRNPGV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NE01-1; Sequence=Displayed; Name=2; IsoId=Q8NE01-2; Sequence=VSP_027082; Name=3; IsoId=Q8NE01-3; Sequence=VSP_027082, VSP_027083

Alternative Sequence

410..457; Missing (in isoform 2 and isoform 3); 694..707; GVPVEGSPGRNPGV -> SLPLLPRGRDSAAYSDSDLFGLSHLVSAVTAFVWP (in isoform 3)

3D Structural Models

Turn

302..308; 309..311; 452..454; 513..515; 571..574

Helix

314..316; 321..323; 335..342; 365..368; 379..385; 399..407; 437..445; 494..507; 509..511; 518..525; 528..530; 544..546; 587..590; 643..654

Beta Strand

318..320; 347..355; 359..364; 373..375; 392..394; 412..420; 423..425; 428..436; 531..534; 538..540; 547..549; 557..563; 566..570; 575..579; 627..634; 636..642

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Compositional Bias

678..691; Polar residues

Domain (FT)

130..308; CNNM transmembrane; 318..379; CBS 1; 386..452; CBS 2

Region

678..707; Disordered

Protein Families

ACDP family

Sequence Similarities

Belongs to the ACDP family.

Clinical Relevance

Antibody

HPA016711

Interaction Protein

ENSG00000127022ENSG00000184007

Interaction Count

Interaction Dataset

biogrid_opencellintact_biogrid