Protein detail
POPD1
Popeye domain-containing protein 1 (Popeye protein 1)
Entry name POPD1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 3 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Popeye domain-containing protein 1 (Popeye protein 1)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Disease related genes
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
49..69; Helical; 71..91; Helical; 93..113; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
HBVESPOP1POPDC1
Gene Description
Blood vessel epicardial substance
Chromosome
6
Position
105096822-105137157
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function (4)
- Disease related genes
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
KEGG (3)
Canonical Pathways
M236 Pid delta np63 pathway
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence24
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | Yes | ||
| tight_junction | tight_junction | Ramilowski_location | Yes | Yes | Yes | ||
| tight_junction | tight_junction | Zhong2015 | Yes | Yes | Yes | ||
| tight_junction | tight_junction | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| POPD1 | Q8NE79 | VAMP3 | Q15836 | Yes | Yes | SIGNOR | SIGNOR:20057356 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36982312 |
Sequence, Structure & Domains
Sequences
Length
360
Mass
41,451
Sequence
MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP
Domain & Motif Annotations
Compositional Bias
337..346; Acidic residues; 350..360; Polar residues
Region
93..115; Required for interaction with CAV3; 136..186; Required for interaction with KCNK2; 317..360; Disordered
Protein Families
Popeye family
Sequence Similarities
Belongs to the popeye family.
Clinical Relevance
Disease Involvement
Limb-girdle muscular dystrophy
Related Diseases
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 30143647 | Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. | Remarkably, transmembrane protein PRR7 is activity-dependently released by neurons via exosomes. |