Protein detail
POPD1
Popeye domain-containing protein 1 (Popeye protein 1)
Entry name POPD1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 3 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Popeye domain-containing protein 1 (Popeye protein 1)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Disease related genes
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
49..69; Helical; 71..91; Helical; 93..113; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Gene Synonym
HBVESPOP1POPDC1
Gene Description
Blood vessel epicardial substance
Chromosome
6
Position
105096822-105137157
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Disease related genes
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component
Molecular Function
Biological Process
KEGG
Canonical Pathways
M236 Pid delta np63 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| lateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| lateral_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| POPD1 | Q8NE79 | VAMP3 | Q15836 | Yes | Yes | No | SIGNOR | SIGNOR:20057356 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36982312 |
Sequence, Structure & Domains
Sequences
Length
360
Mass
41,451
Sequence
MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP
3D Structural Models
Domain & Motif Annotations
Compositional Bias
337..346; Acidic residues; 350..360; Polar residues
Region
93..115; Required for interaction with CAV3; 136..186; Required for interaction with KCNK2; 317..360; Disordered
Protein Families
Popeye family
Sequence Similarities
Belongs to the popeye family.