Protein detail

POPD1

Popeye domain-containing protein 1 (Popeye protein 1)

Entry name POPD1	UniProt ID Q8NE79	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 3	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Popeye domain-containing protein 1 (Popeye protein 1)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Disease related genes
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Transmembrane

49..69; Helical; 71..91; Helical; 93..113; Helical

Transmembrane Count

Ensembl

ENSG00000112276

Entrez Gene Symbol

POPDC1

Gene Synonym (3)

HBVESPOP1POPDC1

Gene Description

Blood vessel epicardial substance

Chromosome

Position

105096822-105137157

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway7

Protein Function (4)

Disease related genes
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (8)

Molecular Function (3)

Biological Process (3)

KEGG (3)

Canonical Pathways

M236 Pid delta np63 pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence24

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
lateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
lateral_cell_membrane	plasma_membrane	Ramilowski_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Ramilowski_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
POPD1	Q8NE79	VAMP3	Q15836	Yes	Yes	No	SIGNOR	SIGNOR:20057356

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	36982312

Sequence, Structure & Domains7

Sequences

Length

360

Mass

41,451

Sequence

MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP

Domain & Motif Annotations

Compositional Bias

337..346; Acidic residues; 350..360; Polar residues

Region

93..115; Required for interaction with CAV3; 136..186; Required for interaction with KCNK2; 317..360; Disordered

Protein Families

Popeye family

Sequence Similarities

Belongs to the popeye family.

Clinical Relevance2

Disease Involvement

Limb-girdle muscular dystrophy

Antibody (2)

HPA014788 HPA018176

Supporting Publications1

PMID	Title	Abstract
30143647	Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.	Remarkably, transmembrane protein PRR7 is activity-dependently released by neurons via exosomes.