Protein detail

NFAM1

NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1)

Protein symbol NFAM1	UniProt ID Q8NET5	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1)

Protein Class

Predicted membrane proteins

Transmembrane

164..184; Helical

Transmembrane Count

Ensembl

ENSG00000235568

Entrez Gene Symbol

NFAM1

Gene Synonym

CNAIP

Gene Description

NFAT activating protein with ITAM motif 1

Chromosome

Position

42380407-42432403

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificSchwann cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor

Function & Pathway

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M153 Pid p75 ntr pathway

Mediation Categories

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NFAM1	SRC	P12931	Y	220	phosphorylation	Li2012
NFAM1	SRC	P12931	Y	231	phosphorylation	Li2012

Ligand-Receptor Signaling

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DENR DOCK11 HSPA14 MCTS1 NFAM1 OTUD6B	O43583 Q0VDF9 Q5JSL3 Q8N6M0 Q8NET5 Q9ULC4	0:0:0:0:0:0	hu.MAP2
	HSPA14 NFAM1	Q0VDF9 Q8NET5	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39535266

Sequence, Structure & Domains

Sequences

Length

270

Mass

29,686

Sequence

MENQPVRWRALPGLPRPPGLPAAPWLLLGVLLLPGTLRLAGGQSVTHTGLPIMASLANTAISFSCRITYPYTPQFKVFTVSYFHEDLQGQRSPKKPTNCHPGLGTENQSHTLDCQVTLVLPGASATGTYYCSVHWPHSTVRGSGTFILVRDAGYREPPQSPQKLLLFGFTGLLSVLSVVGTALLLWNKKRMRGPGKDPTRKCPDPRSASSPKQHPSESVYTALQRRETEVYACIENEDGSSPTAKQSPLSQERPHRFEDDGELNLVYENL

3D Structural Models

Domain & Motif Annotations

Compositional Bias

194..204; Basic and acidic residues; 207..219; Polar residues; 239..250; Polar residues

Domain (CC)

The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.

Domain (FT)

50..150; Ig-like V-type; 209..237; ITAM

Region

190..219; Disordered; 234..262; Disordered

Clinical Relevance

Antibody

HPA031812