Protein detail

RAI3

Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)

Protein symbol RAI3	UniProt ID Q8NFJ5	EVMP score 0.38
Frequency 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)

Protein Class

G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

G-protein coupled receptors:Family 3 (C) receptors
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

34..54; Helical; Name=1; 69..89; Helical; Name=2; 98..118; Helical; Name=3; 130..150; Helical; Name=4; 177..197; Helical; Name=5; 213..233; Helical; Name=6; 248..268; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000013588

Entrez Gene Symbol

GPRC5A

Gene Synonym

PEIG-1RAI3RAIG1TIG1

Gene Description

G protein-coupled receptor class C group 5 member A

Chromosome

Position

12891559-12917937

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

G-protein coupled receptors:Family 3 (C) receptors
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GPRC5A	EGFR	P00533	Y	350	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788
GPRC5A	EGFR	P00533	Y	320	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788
GPRC5A	EGFR	P00533	Y	317	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788
GPRC5A	EGFR	P00533	Y	347	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788

Ligand-Receptor Signaling

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpcr_orphan	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EGFR	P00533	RAI3	Q8NFJ5	Yes	No	Yes	PhosphoSite_norefSIGNORiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:25311788 PhosphoSite:25311788 SIGNOR:25311788

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GPRC5A GTF2F2 HSP90AA2P HSPA9	P13984 P38646 Q14568 Q8NFJ5	0:0:0:0	Havugimana2012	Havugimana2012:C_305
	CHMP2B GOLT1B GPRC5A KIDINS220 RABAC1 TMUB1 XPR1	Q8NFJ5 Q9BVT8 Q9UBH6 Q9UI14 Q9ULH0 Q9UQN3 Q9Y3E0	0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains

Sequences

Length

357

Mass

40,251

Sequence

MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS

3D Structural Models

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 3 family

Sequence Similarities

Belongs to the G-protein coupled receptor 3 family.

Clinical Relevance

Disease Involvement

Tumor suppressor

Antibody

HPA007928 HPA046526