Protein detail

NLGN2

Neuroligin-2

Entry name NLGN2	UniProt ID Q8NFZ4	EVMP confidence score 0.47
Supporting publications (n) 12	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Neuroligin-2

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

678..698; Helical

Transmembrane Count

Ensembl

ENSG00000169992

Entrez Gene Symbol

NLGN2

Gene Synonym

KIAA1366

Gene Description

Neuroligin 2

Chromosome

Position

7404874-7419860

Supporting publications (n)

EVMP confidence score

0.47

Fluorescence & Localization4

Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3

Function & Pathway7

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (15)

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Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence73

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
neuroligin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
neuroligin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (15)

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NLGN2	Q8NFZ4	NRX3B	Q9HDB5	Yes	Yes	No	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NRX3B	Q9HDB5	NLGN2	Q8NFZ4	Yes	Yes	No	CellPhoneDBCellChatDBWangSIGNOR	SIGNOR:22626546 SIGNOR:22626547
NLGN2	Q8NFZ4	NRX3A	Q9Y4C0	Yes	Yes	No	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NRX3A	Q9Y4C0	NLGN2	Q8NFZ4	Yes	Yes	No	CellPhoneDBCellChatDBWangSIGNOR	SIGNOR:22626546 SIGNOR:22626547
NLGN2	Q8NFZ4	NRX1A	Q9ULB1	Yes	Yes	No	iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240 Cellinker:8576240 CellTalkDB:8576240
NRX1A	Q9ULB1	NLGN2	Q8NFZ4	Yes	Yes	No	CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang	HPRD:8576240 SIGNOR:22626542 SIGNOR:22626543
NRX1B	P58400	NLGN2	Q8NFZ4	Yes	Yes	No	CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang	HPRD:8576240 SIGNOR:22626542 SIGNOR:22626543
NLGN2	Q8NFZ4	NRX1B	P58400	Yes	Yes	No	iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240 Cellinker:8576240 CellTalkDB:8576240
NLGN2	Q8NFZ4	NRX2A	Q9P2S2	Yes	Yes	No	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr	Baccin2019:8576240 LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NRX2A	Q9P2S2	NLGN2	Q8NFZ4	Yes	Yes	No	CellChatDBCellPhoneDBSIGNORBaccin2019Ramilowski2015_Baccin2019Wang	SIGNOR:22626544 SIGNOR:22626545

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GABRG2 LHFPL4 NLGN2	P18507 Q7Z7J7 Q8NFZ4	1:1:1	PDB	PDB:9farPDB:9fan
NLGN2	Q8NFZ4	2	PDB	PDB:8gs4
NLGN2 NRXN2 PATJ	Q8NFZ4 Q8NI35 Q9P2S2	1:1:1	CompleatCFinder	Compleat:HC4773

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingFlow cytometryRNA Sequencing	2	33709510 40098346

Sequence, Structure & Domains11

Sequences

Length

835

Mass

90,820

Sequence

MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV

3D Structural Models

Turn

81..84; 116..118; 279..283; 297..299; 500..503; 575..577; 604..607

Helix

121..125; 127..131; 132..134; 193..195; 199..205; 217..221; 233..246; 249..252; 266..276; 304..314; 322..329; 334..338; 364..369; 388..391; 403..417; 424..434; 438..440; 444..459; 461..473; 504..507; 510..512; 525..544; 595..603

Beta Strand

43..45; 50..52; 54..57; 61..63; 65..73; 94..98; 110..112; 135..137; 143..148; 177..183; 186..190; 208..212; 225..228; 254..264; 285..291; 294..296; 300..302; 350..352; 357..360; 377..383; 478..483; 517..519; 545..550; 580..586; 588..591

3D Structure

Electron microscopy (13); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

630..658; Pro residues; 795..818; Pro residues; 823..835; Polar residues

Region

623..668; Disordered; 678..698; Required for interaction with LHFPL4; 790..835; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance1

Antibody (2)

HPA055321 HPA069278

Supporting Publications12

PMID	Title	Abstract
40619995	A 96-Well Ultrafiltration Approach for the High-Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available

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