Protein detail
NLGN2
Neuroligin-2
Entry name NLGN2 | UniProt ID | EVMP score 0.47 |
Frequency 12 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuroligin-2
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
678..698; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1366
Gene Description
Neuroligin 2
Chromosome
17
Position
7404874-7419860
Frequency
12
EVMP Score
0.47
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030424 axon
- GO:0042734 presynaptic membrane
- GO:0043198 dendritic shaft
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0060076 excitatory synapse
- GO:0060077 inhibitory synapse
- GO:0097470 ribbon synapse
- GO:0098690 glycinergic synapse
- GO:0098691 dopaminergic synapse
- GO:0098983 symmetric, GABA-ergic, inhibitory synapse
- GO:0099634 postsynaptic specialization membrane
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | talklr | Yes | No | No | Yes | No |
| ligand | ligand | iTALK | Yes | No | No | Yes | No |
| ligand | ligand | EMBRACE | Yes | No | No | Yes | No |
| ligand | ligand | CellTalkDB | Yes | No | No | Yes | No |
| ligand | ligand | Ramilowski2015 | Yes | No | No | Yes | No |
| ligand | ligand | LRdb | Yes | No | No | Yes | No |
| ligand | ligand | Almen2009 | Yes | No | No | Yes | No |
| neuroligin | ligand | Almen2009 | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
Regulatory Interaction Network
15 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NRX2B | P58401 | NLGN2 | Q8NFZ4 | Yes | Yes | No | CellChatDBCellPhoneDBSIGNORBaccin2019Ramilowski2015_Baccin2019Wang | SIGNOR:22626544SIGNOR:22626545 |
| NLGN2 | Q8NFZ4 | NRX2B | P58401 | Yes | Yes | No | CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr | Baccin2019:8576240LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Cellinker:8576240CellTalkDB:8576240 |
| GEPH | Q9NQX3 | NLGN2 | Q8NFZ4 | Yes | Yes | No | SIGNOR | SIGNOR:25882190 |
| NLGN2 | Q8NFZ4 | MAGI2 | Q86UL8 | Yes | Yes | No | SIGNOR | SIGNOR:22626542 |
| NLGN2 | Q8NFZ4 | DLG4 | P78352 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:18923512HPRD:9278515 |
Page 2 of 2Previous
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
835
Mass
90,820
Sequence
MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
3D Structural Models
Turn
81..84; 116..118; 279..283; 297..299; 500..503; 575..577; 604..607
Helix
121..125; 127..131; 132..134; 193..195; 199..205; 217..221; 233..246; 249..252; 266..276; 304..314; 322..329; 334..338; 364..369; 388..391; 403..417; 424..434; 438..440; 444..459; 461..473; 504..507; 510..512; 525..544; 595..603
Beta Strand
43..45; 50..52; 54..57; 61..63; 65..73; 94..98; 110..112; 135..137; 143..148; 177..183; 186..190; 208..212; 225..228; 254..264; 285..291; 294..296; 300..302; 350..352; 357..360; 377..383; 478..483; 517..519; 545..550; 580..586; 588..591
3D Structure
Electron microscopy (13); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
630..658; Pro residues; 795..818; Pro residues; 823..835; Polar residues
Region
623..668; Disordered; 678..698; Required for interaction with LHFPL4; 790..835; Disordered
Protein Families
Type-B carboxylesterase/lipase family
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.