Protein detail
TSN14
Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
Protein symbol TSN14 | UniProt ID | EVMP score 0.25 |
Frequency 5 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
18..38; Helical; 62..82; Helical; 93..113; Helical; 233..253; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
DC-TM4F2MGC11352TM4SF14
Gene Description
Tetraspanin 14
Chromosome
10
Position
80454265-80533124
Frequency
5
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificCardiomyocytesSingle-Nuclei Brain SpecificLAMP5-LHX6 and Chandelier
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
270
Mass
30,691
Sequence
MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NG11-1; Sequence=Displayed; Name=2; IsoId=Q8NG11-2; Sequence=VSP_011878; Name=3; IsoId=Q8NG11-3; Sequence=VSP_043194
Alternative Sequence
28..150; Missing (in isoform 3); 28..44; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Region
114..232; Necessary and sufficient for interaction with ADAM10
Protein Families
Tetraspanin (TM4SF) family
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.