Protein detail
TSN14
Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
Entry name TSN14 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 5 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
18..38; Helical; 62..82; Helical; 93..113; Helical; 233..253; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
DC-TM4F2MGC11352TM4SF14
Gene Description
Tetraspanin 14
Chromosome
10
Position
80454265-80533124
Supporting publications (n)
5
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue Specificlymphoid tissueCell SpecificCardiomyocytesSingle-Nuclei Brain SpecificLAMP5-LHX6 and Chandelier
Function & Pathway6
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Isolation & Detection Technology (1)
Sequence, Structure & Domains8
Sequences
Length
270
Mass
30,691
Sequence
MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NG11-1; Sequence=Displayed; Name=2; IsoId=Q8NG11-2; Sequence=VSP_011878; Name=3; IsoId=Q8NG11-3; Sequence=VSP_043194
Alternative Sequence
28..150; Missing (in isoform 3); 28..44; Missing (in isoform 2)
Domain & Motif Annotations
Region
114..232; Necessary and sufficient for interaction with ADAM10
Protein Families
Tetraspanin (TM4SF) family
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 29603567 | Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins. | No abstract available |
| 30865381 | Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114. | No abstract available |
| 31753726 | Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. | No abstract available |
| 36028467 | Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment. | No abstract available |
| 41167904 | Accessing the proteome of extracellular vesicles via rapid acoustic isolation of a minute human blood plasma sample. | No abstract available |