Protein detail
VANG1
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Protein symbol VANG1 | UniProt ID | EVMP score 0.88 |
Frequency 26 | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Disease related genes
Transmembrane
118..138; Helical; Name=1; 152..172; Helical; Name=2; 183..203; Helical; Name=3; 223..243; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
STB2
Gene Description
VANGL planar cell polarity protein 1
Chromosome
1
Position
115641970-115698224
Frequency
26
EVMP Score
0.88
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013405 rhod gtpase cycle
- R-hsa-9035034 rhof gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9013407 rhoh gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-9013424 rhov gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696270 rnd2 gtpase cycle
- R-hsa-9696264 rnd3 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | iTALK | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains
Sequences
Length
524
Mass
59,975
Sequence
MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TAA9-1; Sequence=Displayed; Name=2; IsoId=Q8TAA9-2; Sequence=VSP_008742
Alternative Sequence
67..68; Missing (in isoform 2)
3D Structural Models
Turn
139..141; 207..212; 243..245; 257..259; 415..417; 455..457
Helix
115..137; 147..171; 184..206; 216..242; 272..286; 292..294; 296..306; 328..338; 342..369; 390..397; 398..400; 402..411; 420..432; 437..445; 450..452; 509..511
Beta Strand
250..256; 262..267; 372..375; 386..388; 463..469; 480..484; 489..496; 500..504; 514..517
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
1..15; Low complexity; 73..85; Polar residues
Region
1..85; Disordered
Protein Families
Vang family
Sequence Similarities
Belongs to the Vang family.