Protein detail

VANG1

Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)

Entry name
VANG1
UniProt ID
Q8TAA9
EVMP confidence score
0.88
Supporting publications (n)
26
Transmembrane count
4
Protein classification
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
  • Transporters
  • Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
  • Potential drug targets
  • Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
  • Disease related genes
Transmembrane
118..138; Helical; Name=1; 152..172; Helical; Name=2; 183..203; Helical; Name=3; 223..243; Helical; Name=4
Transmembrane Count
4
Ensembl
ENSG00000173218
Entrez Gene Symbol
VANGL1
Gene Synonym
STB2
Gene Description
VANGL planar cell polarity protein 1
Chromosome
1
Position
115641970-115698224
Supporting publications (n)
26
EVMP confidence score
0.88
Function & Pathway7
Protein Function (5)
  • Transporters
  • Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
  • Potential drug targets
  • Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
  • Disease related genes
Cellular Component (3)
Molecular Function
GO:0005515 protein binding
Biological Process (3)
KEGG (2)
Reactome (20)
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Mediation Categories
Receptor-signaling mediation
Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneTopDBNoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
receptorreceptoriTALKNoYesNoNoNo
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
VANGL1Q8TAA96PDBPDB:9jk6PDB:8zxdPDB:9jk8PDB:9jk9

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationMass spectrometry137427430
Sequence, Structure & Domains13

Sequences

Length
524
Mass
59,975
Sequence
MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TAA9-1; Sequence=Displayed; Name=2; IsoId=Q8TAA9-2; Sequence=VSP_008742
Alternative Sequence
67..68; Missing (in isoform 2)

3D Structural Models

Turn
139..141; 207..212; 243..245; 257..259; 415..417; 455..457
Helix
115..137; 147..171; 184..206; 216..242; 272..286; 292..294; 296..306; 328..338; 342..369; 390..397; 398..400; 402..411; 420..432; 437..445; 450..452; 509..511
Beta Strand
250..256; 262..267; 372..375; 386..388; 463..469; 480..484; 489..496; 500..504; 514..517
3D Structure
Electron microscopy (4)

Domain & Motif Annotations

Compositional Bias
1..15; Low complexity; 73..85; Polar residues
Region
1..85; Disordered
Protein Families
Vang family
Sequence Similarities
Belongs to the Vang family.
Clinical Relevance5
Disease Involvement
Disease variant
Antibody (2)
HPA025235CAB076375
Interaction Protein
ENSG00000070159
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications26
PMIDTitleAbstract
25844599Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.No abstract available
26775013Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.No abstract available
26801919Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.No abstract available
26884841Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis.No abstract available
27312428A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer.No abstract available
28242843Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.No abstract available
28396511Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker.No abstract available
30550287Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.No abstract available
30608700Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs.No abstract available
30760538Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.No abstract available
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