Protein detail

VANG1

Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)

Entry name VANG1	UniProt ID Q8TAA9	EVMP confidence score 0.88
Supporting publications (n) 26	Transmembrane count 4	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (5)

Transporters
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Disease related genes

Transmembrane

118..138; Helical; Name=1; 152..172; Helical; Name=2; 183..203; Helical; Name=3; 223..243; Helical; Name=4

Transmembrane Count

Ensembl

ENSG00000173218

Entrez Gene Symbol

VANGL1

Gene Synonym

STB2

Gene Description

VANGL planar cell polarity protein 1

Chromosome

Position

115641970-115698224

Supporting publications (n)

EVMP confidence score

0.88

Function & Pathway7

Protein Function (5)

Transporters
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Disease related genes

Cellular Component (3)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG (2)

Reactome (20)

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Mediation Categories

Receptor-signaling mediation

Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	iTALK	No	Yes	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	VANGL1	Q8TAA9	6	PDB	PDB:9jk6PDB:8zxdPDB:9jk8PDB:9jk9

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	37427430

Sequence, Structure & Domains13

Sequences

Length

524

Mass

59,975

Sequence

MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TAA9-1; Sequence=Displayed; Name=2; IsoId=Q8TAA9-2; Sequence=VSP_008742

Alternative Sequence

67..68; Missing (in isoform 2)

3D Structural Models

Turn

139..141; 207..212; 243..245; 257..259; 415..417; 455..457

Helix

115..137; 147..171; 184..206; 216..242; 272..286; 292..294; 296..306; 328..338; 342..369; 390..397; 398..400; 402..411; 420..432; 437..445; 450..452; 509..511

Beta Strand

250..256; 262..267; 372..375; 386..388; 463..469; 480..484; 489..496; 500..504; 514..517

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Compositional Bias

1..15; Low complexity; 73..85; Polar residues

Region

1..85; Disordered

Protein Families

Vang family

Sequence Similarities

Belongs to the Vang family.

Clinical Relevance5

Disease Involvement

Disease variant

Antibody (2)

HPA025235 CAB076375

Interaction Protein

ENSG00000070159

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications26

PMID	Title	Abstract
30975894	Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation.	No abstract available
31320591	Exosomes regulate neurogenesis and circuit assembly.	No abstract available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
31685984	Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.	Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosomes from brain metastatic but not lung or bone metastatic cells.
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
36332889	A comparative Proteomics Analysis Identified Differentially Expressed Proteins in Pancreatic Cancer-Associated Stellate Cell Small Extracellular Vesicles.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available

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