Protein detail
VANG1
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Entry name VANG1 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 26 | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Transporters
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Disease related genes
Transmembrane
118..138; Helical; Name=1; 152..172; Helical; Name=2; 183..203; Helical; Name=3; 223..243; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
STB2
Gene Description
VANGL planar cell polarity protein 1
Chromosome
1
Position
115641970-115698224
Supporting publications (n)
26
EVMP confidence score
0.63
Function & Pathway
Protein Function (5)
- Transporters
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Disease related genes
Cellular Component (3)
Molecular Function
Biological Process (3)
Reactome (20)
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013405 rhod gtpase cycle
- R-hsa-9035034 rhof gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
Page 1 of 2
Mediation Categories
Receptor-signaling mediation
Relations & Evidence14
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | EMBRACE | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius |
Page 2 of 2Previous
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains
Sequences
Length
524
Mass
59,975
Sequence
MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TAA9-1; Sequence=Displayed; Name=2; IsoId=Q8TAA9-2; Sequence=VSP_008742
Alternative Sequence
67..68; Missing (in isoform 2)
3D Structural Models
Turn
139..141; 207..212; 243..245; 257..259; 415..417; 455..457
Helix
115..137; 147..171; 184..206; 216..242; 272..286; 292..294; 296..306; 328..338; 342..369; 390..397; 398..400; 402..411; 420..432; 437..445; 450..452; 509..511
Beta Strand
250..256; 262..267; 372..375; 386..388; 463..469; 480..484; 489..496; 500..504; 514..517
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
1..15; Low complexity; 73..85; Polar residues
Region
1..85; Disordered
Protein Families
Vang family
Sequence Similarities
Belongs to the Vang family.
Clinical Relevance
Supporting Publications26
| PMID | Title | Related sentences |
|---|---|---|
| 30975894 | Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation. | No related sentences available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No related sentences available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No related sentences available |
| 31685984 | Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. | Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosomes from brain metastatic but not lung or bone metastatic cells. |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No related sentences available |
| 36332889 | A comparative Proteomics Analysis Identified Differentially Expressed Proteins in Pancreatic Cancer-Associated Stellate Cell Small Extracellular Vesicles. | No related sentences available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No related sentences available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No related sentences available |