Protein detail

PRR7

Proline-rich protein 7 (Synaptic proline-rich membrane protein)

Entry name PRR7	UniProt ID Q8TB68	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Proline-rich protein 7 (Synaptic proline-rich membrane protein)

Protein Class

Predicted intracellular proteinsTransporters

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

10..30; Helical; Signal-anchor for type III membrane protein

Transmembrane Count

Ensembl

ENSG00000131188

Entrez Gene Symbol

PRR7

Gene Synonym

MGC10772

Gene Description

Proline rich 7, synaptic

Chromosome

Position

177446445-177456286

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificEpendymal cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cellsSecretome LocationSecreted to extracellular matrixSecretome FunctionDevelopmental protein

Function & Pathway

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
JUN-FBW7-PRR7 complex	FBXW7 JUN PRR7	P05412 Q8TB68 Q969H0	0:0:0	CORUM	CORUM:6975	27458189

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	9	39558134 30408591 35212939 32284825 35611462 29436780 39940923 39505756 28986585

Sequence, Structure & Domains

Sequences

Length

274

Mass

30,930

Sequence

MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPHRSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TB68-1; Sequence=Displayed; Name=2; IsoId=Q8TB68-2; Sequence=VSP_032750

Alternative Sequence

89..109; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

90..102; Basic residues; 111..122; Basic residues; 123..137; Pro residues

Motif

272..274; PDZ-binding

Region

1..44; Required for interaction with NMDA receptors; 2..39; Required for membrane localization; 63..148; Disordered; 151..274; Required for apoptosis induction; 151..171; Required for internalization

Clinical Relevance

Antibody

HPA046636

Interaction Protein

ENSG00000069869

Interaction Count

Interaction Dataset

intact_biogrid