Protein detail
PRR7
Proline-rich protein 7 (Synaptic proline-rich membrane protein)
Entry name PRR7 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Proline-rich protein 7 (Synaptic proline-rich membrane protein)
Protein Class (2)
Predicted intracellular proteinsTransporters
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
10..30; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC10772
Gene Description
Proline rich 7, synaptic
Chromosome
5
Position
177446445-177456286
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization8
Tissue SpecificbrainCell SpecificEpendymal cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cellsSecretome LocationSecreted to extracellular matrixSecretome FunctionDevelopmental protein
Function & Pathway5
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (9)
Molecular Function (5)
Biological Process (3)
Mediation Categories
Immune mediation
Relations & Evidence20
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains8
Sequences
Length
274
Mass
30,930
Sequence
MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPHRSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TB68-1; Sequence=Displayed; Name=2; IsoId=Q8TB68-2; Sequence=VSP_032750
Alternative Sequence
89..109; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
90..102; Basic residues; 111..122; Basic residues; 123..137; Pro residues
Motif
272..274; PDZ-binding
Region
1..44; Required for interaction with NMDA receptors; 2..39; Required for membrane localization; 63..148; Disordered; 151..274; Required for apoptosis induction; 151..171; Required for internalization
Clinical Relevance4
Antibody
Interaction Protein
ENSG00000069869
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40222457 | Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement. | No abstract available |