Protein detail
S22A8
Organic anion transporter 3 (hOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8)
Protein symbol S22A8 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 11 | Protein classification FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Organic anion transporter 3 (hOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8)
Protein Class
FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
10..30; Helical; 124..144; Helical; 155..175; Helical; 177..197; Helical; 213..233; Helical; 237..257; Helical; 328..348; Helical; 355..375; Helical; 387..407; Helical; 412..432; Helical; 472..492; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
OAT3
Gene Description
Solute carrier family 22 member 8
Chromosome
11
Position
62989154-63015841
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificFibro-adipogenic progenitorsSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 14 | 3371834237862381389386743994949026538482315085003887173037702715327954143007131837033249376863664009834633114768 |
Sequence, Structure & Domains
Sequences
Length
542
Mass
59,856
Sequence
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8TCC7-1; Sequence=Displayed; Name=2; IsoId=Q8TCC7-2; Sequence=VSP_022565; Name=5; IsoId=Q8TCC7-5; Sequence=VSP_045824; Name=3; IsoId=Q8TCC7-3; Sequence=VSP_022562, VSP_022563, VSP_022564; Name=4; IsoId=Q8TCC7-4; Sequence=VSP_045272
Alternative Sequence
1..345; Missing (in isoform 3); 1..123; Missing (in isoform 5); 1..91; Missing (in isoform 4); 406..455; DLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRV -> GERLGLPQNPLEEAARLGARDFTAGSASKSLCYLEQVPALSGAQGLSSRK (in isoform 3); 456..542; Missing (in isoform 3); 510; W -> WSVTASGPPR (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
517..527; Basic and acidic residues
Region
515..542; Disordered
Protein Families
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved; Phase 2
Drug Targets
FDA approved drug targets
Drugs
Antibody