Protein detail
SPP2A
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
Entry name SPP2A | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 27 | Transmembrane count 9 | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (6)
- Potential drug targets
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Transporters:Transporter channels and pores
- Disease related genes
- Peptidases:Aspartic-type peptidases
Transmembrane
173..193; Helical; 221..241; Helical; 248..268; Helical; 286..306; Helical; 312..332; Helical; 341..361; Helical; 400..420; Helical; 438..458; Helical; 461..481; Helical
Transmembrane Count
9
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
IMP3PSL2
Gene Description
Signal peptide peptidase like 2A
Chromosome
15
Position
50702266-50765948
Supporting publications (n)
27
EVMP confidence score
0.63
Fluorescence & Localization2
Tissue Specificblood vesselCell SpecificThymocytes
Function & Pathway7
Protein Function (6)
- Potential drug targets
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Transporters:Transporter channels and pores
- Disease related genes
- Peptidases:Aspartic-type peptidases
Cellular Component (10)
- GO:0005765 lysosomal membrane
- GO:0005770 late endosome
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0030660 Golgi-associated vesicle membrane
- GO:0031902 late endosome membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
- GO:0098553 lumenal side of endoplasmic reticulum membrane
- GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M240 Pid syndecan 2 pathway
- M276 Pid fgf pathway
- M100 Pid shp2 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | R SequencingMass spectrometry | 23 | 3371834239290459399494903150850038225453398737263887173032795414268019192772398430071318337095103097589437686366400983463076053831366407403116164009145533114768304513714131576731320591 |
Sequence, Structure & Domains8
Sequences
Length
520
Mass
58,143
Sequence
MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
Domain & Motif Annotations
Motif
463..465; PAL; 495..498; YXXo lysosomal targeting motif
Domain (CC)
The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP. The C-terminal tail is necessary for lysosomal transport.
Domain (FT)
63..151; PA
Protein Families
Peptidase A22B family
Sequence Similarities
Belongs to the peptidase A22B family.
Supporting Publications27
| PMID | Title | Abstract |
|---|---|---|
| 22106071 | Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). | No abstract available |
| 2353145 | [The Cronkhite-Canada syndrome]. | No abstract available |
| 25471207 | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | No abstract available |
| 26538482 | Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles. | No abstract available |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 27723984 | Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection. | No abstract available |
| 28242843 | Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. | No abstract available |
| 30353492 | Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
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