Protein detail
SPP2A
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
Entry name SPP2A | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 27 | Transmembrane count 9 | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (6)
- Potential drug targets
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Transporters:Transporter channels and pores
- Disease related genes
- Peptidases:Aspartic-type peptidases
Transmembrane
173..193; Helical; 221..241; Helical; 248..268; Helical; 286..306; Helical; 312..332; Helical; 341..361; Helical; 400..420; Helical; 438..458; Helical; 461..481; Helical
Transmembrane Count
9
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
IMP3PSL2
Gene Description
Signal peptide peptidase like 2A
Chromosome
15
Position
50702266-50765948
Supporting publications (n)
27
EVMP confidence score
0.63
Fluorescence & Localization2
Tissue Specificblood vesselCell SpecificThymocytes
Function & Pathway7
Protein Function (6)
- Potential drug targets
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Transporters:Transporter channels and pores
- Disease related genes
- Peptidases:Aspartic-type peptidases
Cellular Component (10)
- GO:0005765 lysosomal membrane
- GO:0005770 late endosome
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0030660 Golgi-associated vesicle membrane
- GO:0031902 late endosome membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
- GO:0098553 lumenal side of endoplasmic reticulum membrane
- GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M240 Pid syndecan 2 pathway
- M276 Pid fgf pathway
- M100 Pid shp2 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | R SequencingMass spectrometry | 23 | 3371834239290459399494903150850038225453398737263887173032795414268019192772398430071318337095103097589437686366400983463076053831366407403116164009145533114768304513714131576731320591 |
Sequence, Structure & Domains8
Sequences
Length
520
Mass
58,143
Sequence
MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
Domain & Motif Annotations
Motif
463..465; PAL; 495..498; YXXo lysosomal targeting motif
Domain (CC)
The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP. The C-terminal tail is necessary for lysosomal transport.
Domain (FT)
63..151; PA
Protein Families
Peptidase A22B family
Sequence Similarities
Belongs to the peptidase A22B family.
Supporting Publications27
| PMID | Title | Abstract |
|---|---|---|
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33580265 | Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 36332889 | A comparative Proteomics Analysis Identified Differentially Expressed Proteins in Pancreatic Cancer-Associated Stellate Cell Small Extracellular Vesicles. | No abstract available |
| 36406491 | Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |