Protein detail

MO2R1

Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)

Entry name MO2R1	UniProt ID Q8TD46	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)

Protein Function

Predicted intracellular proteins

Transmembrane

266..286; Helical

Transmembrane Count

Ensembl

ENSG00000163606

Entrez Gene Symbol

CD200R1

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (4)

Biological Process (3)

KEGG

hsa05167 Kaposi sarcoma-associated herpesvirus infection

Reactome (2)

Canonical Pathways (3)

M184 Pid ecadherin keratinocyte pathway
M72 Pid nectin pathway
M266 Pid ncadherin pathway

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence46

Ligand-Receptor Signaling (45)

45 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	OmniPath	Yes	No	Yes	Yes	No
extracellular	extracellular	DGIdb	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture	Mass spectrometry	15	26826536 38113368 40465195 35359923 36497184 34064677 40189497 32854315 40985879 37563857 41307968 36146834 31805958 38207106 39207047

Sequence, Structure & Domains9

Sequences

Length

348

Mass

39,041

Sequence

MLCPWRTANLGLLLILTIFLVAEAEGAAQPNNSLMLQTSKENHALASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTDERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAHISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKLYIPYIILTIIILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNPLYDTTNKVKASEALQSEVDTDLHTL

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q8TD46-4; Sequence=Displayed; Name=1; IsoId=Q8TD46-1; Sequence=VSP_061888; Name=2; IsoId=Q8TD46-2; Sequence=VSP_061889, VSP_061890; Name=3; IsoId=Q8TD46-3; Sequence=VSP_061888, VSP_061889, VSP_061890

Alternative Sequence

22..45; AEAEGAAQPNNSLMLQTSKENHAL -> A (in isoform 1 and isoform 3); 174..188; VTPEVTLFQNRNRTA -> GKEHHILRYFTSPDL (in isoform 2 and isoform 3); 189..348; Missing (in isoform 2 and isoform 3)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

160..251; Ig-like C2-type

Protein Families

CD200R family

Sequence Similarities

Belongs to the CD200R family.

Supporting Publications1

PMID	Title	Abstract
37862381	Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.	No abstract available