Protein detail
FRS2
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Entry name FRS2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway8
Protein Function
Predicted intracellular proteins
Cellular Component (7)
Molecular Function (5)
Biological Process (3)
KEGG (3)
Reactome (50)
- R-hsa-9028731 activated ntrk2 signals through frs2 and frs3
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5654687 downstream signaling of activated fgfr1
- R-hsa-5654696 downstream signaling of activated fgfr2
- R-hsa-5654708 downstream signaling of activated fgfr3
- R-hsa-5654716 downstream signaling of activated fgfr4
- R-hsa-5654693 frs mediated fgfr1 signaling
- R-hsa-5654700 frs mediated fgfr2 signaling
- R-hsa-5654706 frs mediated fgfr3 signaling
Page 1 of 5
Canonical Pathways
M81 Pid cdc42 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence25
Enzyme-Mediated Modification (6)
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FRS2 | PTPN11 | Q06124 | Y | 436 | dephosphorylation | HPRD | HPRD:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 196 | phosphorylation | KEASparser_ProtMapperProtMapper | ProtMapper:25394172KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 306 | phosphorylation | KEA | KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 349 | phosphorylation | KEA | KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 392 | phosphorylation | KEA | KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 436 | phosphorylation | KEA | KEA:9632781 |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (11)
11 records.
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Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Frs2-Grb2-Shp2 complexFGF stimulated | FRS2GRB2PTPN11PTPN6 | P29350P62993Q06124Q8WU20 | 1:1:1:1 | Compleat | Compleat:HC958 | 9632781 |
| Frs2-Shp2 complexFGF stimulated | FRS2PTPN11PTPN6 | P29350Q06124Q8WU20 | 1:1:1 | Compleat | Compleat:HC3583 | 9632781 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33893753 |
Sequence, Structure & Domains10
Sequences
Length
508
Mass
57,029
Sequence
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
3D Structural Models
Turn
15..18; 50..52; 59..61
Helix
94..107
Beta Strand
20..26; 32..34; 36..40; 45..49; 53..57; 62..67; 69..76; 84..90
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
122..131; Basic and acidic residues; 227..240; Basic and acidic residues; 276..286; Polar residues; 325..338; Polar residues
Domain (FT)
13..115; IRS-type PTB
Region
122..180; Disordered; 200..243; Disordered; 270..297; Disordered; 315..338; Disordered; 366..385; Disordered; 441..467; Disordered; 483..508; Disordered
Clinical Relevance3
Interaction Protein
ENSG00000179295
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |