Protein detail
FRS2
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Protein symbol FRS2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count | Protein classification |
Basic Information
Protein Names
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9028731 activated ntrk2 signals through frs2 and frs3
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5654687 downstream signaling of activated fgfr1
- R-hsa-5654696 downstream signaling of activated fgfr2
- R-hsa-5654708 downstream signaling of activated fgfr3
- R-hsa-5654716 downstream signaling of activated fgfr4
- R-hsa-5654693 frs mediated fgfr1 signaling
- R-hsa-5654700 frs mediated fgfr2 signaling
- R-hsa-5654706 frs mediated fgfr3 signaling
- R-hsa-5654712 frs mediated fgfr4 signaling
- R-hsa-74751 insulin receptor signalling cascade
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-112399 irs mediated signalling
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-5654726 negative regulation of fgfr1 signaling
- R-hsa-5654727 negative regulation of fgfr2 signaling
- R-hsa-5654732 negative regulation of fgfr3 signaling
- R-hsa-5654733 negative regulation of fgfr4 signaling
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-9675108 nervous system development
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-5654689 pi 3k cascade fgfr1
- R-hsa-5654695 pi 3k cascade fgfr2
- R-hsa-5654710 pi 3k cascade fgfr3
- R-hsa-5654720 pi 3k cascade fgfr4
- R-hsa-169893 prolonged erk activation events
- R-hsa-8853659 ret signaling
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696270 rnd2 gtpase cycle
- R-hsa-201556 signaling by alk
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-190236 signaling by fgfr
- R-hsa-5654736 signaling by fgfr1
- R-hsa-5655302 signaling by fgfr1 in disease
- R-hsa-5654738 signaling by fgfr2
- R-hsa-5655253 signaling by fgfr2 in disease
- R-hsa-5654741 signaling by fgfr3
- R-hsa-5654743 signaling by fgfr4
- R-hsa-5655291 signaling by fgfr4 in disease
- R-hsa-1226099 signaling by fgfr in disease
- R-hsa-74752 signaling by insulin receptor
- R-hsa-9006115 signaling by ntrk2 trkb
- R-hsa-166520 signaling by ntrks
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-2404192 signaling by type 1 insulin like growth factor 1 receptor igf1r
- R-hsa-187687 signalling to erks
Canonical Pathways
M81 Pid cdc42 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FRS2 | PTPN11 | Q06124 | Y | 436 | dephosphorylation | HPRD | HPRD:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 196 | phosphorylation | KEASparser_ProtMapperProtMapper | ProtMapper:25394172KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 306 | phosphorylation | KEA | KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 349 | phosphorylation | KEA | KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 392 | phosphorylation | KEA | KEA:9632781 |
| FRS2 | FGFR1 | P11362 | Y | 436 | phosphorylation | KEA | KEA:9632781 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FGFR2 | P21802 | FRS2 | Q8WU20 | Yes | Yes | Yes | WangCui2007SIGNORACSN | ACSN:15567848ACSN:15574420ACSN:17496910ACSN:14585353ACSN:15173823ACSN:12040186ACSN:19568798SIGNOR:9182757ACSN:16488589ACSN:6321473ACSN:11997436ACSN:11274345ACSN:11777939ACSN:11447289 |
Page 2 of 2Previous
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Frs2-Grb2-Shp2 complexFGF stimulated | FRS2GRB2PTPN11PTPN6 | P29350P62993Q06124Q8WU20 | 1:1:1:1 | Compleat | Compleat:HC958 | 9632781 |
| Frs2-Shp2 complexFGF stimulated | FRS2PTPN11PTPN6 | P29350Q06124Q8WU20 | 1:1:1 | Compleat | Compleat:HC3583 | 9632781 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33893753 |
Sequence, Structure & Domains
Sequences
Length
508
Mass
57,029
Sequence
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
3D Structural Models
Turn
15..18; 50..52; 59..61
Helix
94..107
Beta Strand
20..26; 32..34; 36..40; 45..49; 53..57; 62..67; 69..76; 84..90
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
122..131; Basic and acidic residues; 227..240; Basic and acidic residues; 276..286; Polar residues; 325..338; Polar residues
Domain (FT)
13..115; IRS-type PTB
Region
122..180; Disordered; 200..243; Disordered; 270..297; Disordered; 315..338; Disordered; 366..385; Disordered; 441..467; Disordered; 483..508; Disordered
Clinical Relevance
Interaction Protein
ENSG00000179295
Interaction Count
1
Interaction Dataset
intact_biogrid