Protein detail
S38A5
Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)
Entry name S38A5 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 5 | Transmembrane count 11 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
49..71; Helical; 88..108; Helical; 126..146; Helical; 167..187; Helical; 193..213; Helical; 258..278; Helical; 296..316; Helical; 335..355; Helical; 377..397; Helical; 400..420; Helical; 440..460; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
JM24SN2
Gene Description
Solute carrier family 38 member 5
Chromosome
X
Position
48458537-48470260
Supporting publications (n)
5
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificFoveolar cells
Function & Pathway8
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function (9)
- GO:0005290 L-histidine transmembrane transporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015182 L-asparagine transmembrane transporter activity
- GO:0015186 L-glutamine transmembrane transporter activity
- GO:0015187 glycine transmembrane transporter activity
- GO:0015194 L-serine transmembrane transporter activity
- GO:0022858 alanine transmembrane transporter activity
- GO:0140830 L-glutamine, sodium:proton antiporter activity
- GO:0140893 neutral amino acid, sodium:proton antiporter activity
Biological Process (3)
Reactome (3)
Canonical Pathways (3)
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence21
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| slc38 | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33893753 |
Sequence, Structure & Domains7
Sequences
Length
472
Mass
51,457
Sequence
MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WUX1-1; Sequence=Displayed; Name=2; IsoId=Q8WUX1-2; Sequence=VSP_029702
Alternative Sequence
1..51; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
Amino acid/polyamine transporter 2 family
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.
Clinical Relevance1
Antibody
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |